1 Ocak 2023 Dergi makalesi Açık Erişim

Karoglu-Eravsar, Elif Tugce; Tuz-Sasik, Melek Umay; Karaduman, Aysenur; Keskus, Ayse Gokce; Arslan-Ergul, Ayca; Konu, Ozlen; Kafaligonul, Hulusi; Adams, Michelle M.

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{
  "DOI": "10.1159/000534343", 
  "abstract": "<p>Introduction: Interventions targeting cholinergic neurotransmission like acetylcholinesterase (AChE) inhibition distinguish potential mechanisms to delay age-related impairments and attenuate deficits related to neurodegenerative diseases. However, the chronic effects of these interventions are not well-described. Methods: In the current study, global levels of cholinergic, cellular, synaptic, and inflammation-mediating proteins were assessed within the context of aging and chronic reduction of AChE activity. Long-term depletion of AChE activity was induced by using a mutant zebrafish line and they were compared with the wildtype group at young and old ages. Results: Results demonstrated that AChE activity was lower in both young and old mutants and this decrease coincided with a reduction in ACh content. Additionally, an overall age-related reduction in AChE activity and the AChE/ACh ratio was observed, this decline was more prominent in wildtype groups. The levels of an immature neuronal marker were upregulated in mutants, while a glial marker showed an overall reduction. Mutants had preserved levels of inhibitory and presynaptic elements with aging, whereas glutamate receptor subunit levels declined. Discussion/Conclusion: Long-term AChE activity depletion induces synaptic and cellular alterations. These data provide further insights into molecular targets and adaptive responses following the long-term reduction of AChE activity that was also targeted pharmacologically to treat neurodegenerative diseases in human subjects.</p>", 
  "author": [
    {
      "family": "Karoglu-Eravsar", 
      "given": " Elif Tugce"
    }, 
    {
      "family": "Tuz-Sasik", 
      "given": " Melek Umay"
    }, 
    {
      "family": "Karaduman", 
      "given": " Aysenur"
    }, 
    {
      "family": "Keskus", 
      "given": " Ayse Gokce"
    }, 
    {
      "family": "Arslan-Ergul", 
      "given": " Ayca"
    }, 
    {
      "family": "Konu", 
      "given": " Ozlen"
    }, 
    {
      "family": "Kafaligonul", 
      "given": " Hulusi"
    }, 
    {
      "family": "Adams", 
      "given": " Michelle M."
    }
  ], 
  "container_title": "GERONTOLOGY", 
  "id": "270528", 
  "issue": "12", 
  "issued": {
    "date-parts": [
      [
        2023, 
        1, 
        1
      ]
    ]
  }, 
  "page": "13", 
  "title": "Long-term Acetylcholinesterase Depletion Alters the Levels of Key Synaptic Proteins while Maintaining Neuronal Markers in the Aging Zebrafish (Danio rerio) Brain", 
  "type": "article-journal", 
  "volume": "69"
}