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Resolution of (+/-)-beta-Methylphenylethylamine by a Novel Chiral Stationary Phase for Pirkle-Type Column Chromatography

Yilmaz, Hayrullah; Topal, Giray; Cakmak, Resit; Hosgoren, Halil


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        "affiliation": "Dicle Univ, Fac Educ, Dept Chem, TR-21280 Diyarbakir, Turkey", 
        "name": "Yilmaz, Hayrullah"
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      {
        "affiliation": "Dicle Univ, Fac Educ, Dept Chem, TR-21280 Diyarbakir, Turkey", 
        "name": "Topal, Giray"
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      {
        "affiliation": "Dicle Univ, Fac Educ, Dept Chem, TR-21280 Diyarbakir, Turkey", 
        "name": "Cakmak, Resit"
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      {
        "affiliation": "Dicle Univ, Fac Sci & Arts, Dept Chem, TR-21280 Diyarbakir, Turkey", 
        "name": "Hosgoren, Halil"
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    "description": "In this study, a new Pirkle-type chiral column stationary phase for resolution of beta-methylphenylethyl amine was described by using activated Sepharose 4B as a matrix, L-tyrosine as a spacer arm, and an aromatic amine derivative of L-glutamic acid as a ligand. The binding capacities of the stationary phase were determined at different pH values (pH = 6, 7, and 8) using buffer solutions as mobile phase, and enantiomeric excess (ee) was determined by HPLC equipped with chiral column. The ee was found to be 47%. Chirality 22:252-257, 2010. (C) 2009 Wiley-Liss, Inc.", 
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    "title": "Resolution of (+/-)-beta-Methylphenylethylamine by a Novel Chiral Stationary Phase for Pirkle-Type Column Chromatography"
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