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Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis

Zhang, Yun; Donaher, Joana Liu; Das, Sunny; Li, Xin; Reinhardt, Ferenc; Krall, Jordan A.; Lambert, Arthur W.; Thiru, Prathapan; Keys, Heather R.; Khan, Mehreen; Hofree, Matan; Wilson, Molly M.; Yedier-Bayram, Ozlem; Lack, Nathan A.; Onder, Tamer T.; Bagci-Onder, Tugba; Tyler, Michael; Tirosh, Itay; Regev, Aviv; Lees, Jacqueline A.; Lees, Jacqueline A.


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      "@type": "Person", 
      "affiliation": "Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA", 
      "name": "Zhang, Yun"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA", 
      "name": "Donaher, Joana Liu"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA", 
      "name": "Das, Sunny"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA", 
      "name": "Li, Xin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA", 
      "name": "Reinhardt, Ferenc"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA", 
      "name": "Krall, Jordan A."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA", 
      "name": "Lambert, Arthur W."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA", 
      "name": "Thiru, Prathapan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA", 
      "name": "Keys, Heather R."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA", 
      "name": "Khan, Mehreen"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA", 
      "name": "Hofree, Matan"
    }, 
    {
      "@type": "Person", 
      "name": "Wilson, Molly M."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Koc Univ, Sch Med, Istanbul, Turkey", 
      "name": "Yedier-Bayram, Ozlem"
    }, 
    {
      "@type": "Person", 
      "name": "Lack, Nathan A."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Koc Univ, Sch Med, Istanbul, Turkey", 
      "name": "Onder, Tamer T."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Koc Univ, Sch Med, Istanbul, Turkey", 
      "name": "Bagci-Onder, Tugba"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Weizmann Inst Sci, Dept Mol Cell Biol, Rehovot, Israel", 
      "name": "Tyler, Michael"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Weizmann Inst Sci, Dept Mol Cell Biol, Rehovot, Israel", 
      "name": "Tirosh, Itay"
    }, 
    {
      "@type": "Person", 
      "name": "Regev, Aviv"
    }, 
    {
      "@type": "Person", 
      "name": "Lees, Jacqueline A."
    }, 
    {
      "@type": "Person", 
      "name": "Lees, Jacqueline A."
    }
  ], 
  "datePublished": "2022-01-01", 
  "description": "Through genome-wide and focused CRISPR screens, Zhang et al. discover that loss of PRC2 or KMT2D-COMPASS enables distinct EMT trajectories, which exert differential effects on the metastatic capability of carcinoma cells.", 
  "headline": "Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis", 
  "identifier": 259629, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis", 
  "url": "https://aperta.ulakbim.gov.tr/record/259629"
}
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