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Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis

2022    Zhang, Yun; Donaher, Joana Liu; Das, Sunny; Li, Xin; Reinhardt, Ferenc; Krall, Jordan A.; Lambert, Arthur W.; Thiru, Prathapan; Keys, Heather R.; Khan, Mehreen; Hofree, Matan; Wilson, Molly M.; Yedier-Bayram, Ozlem; Lack, Nathan A.; Onder, Tamer T.; Bagci-Onder, Tugba; Tyler, Michael; Tirosh, Itay; Regev, Aviv; Lees, Jacqueline A.; Lees, Jacqueline A.

Through genome-wide and focused CRISPR screens, Zhang et al. discover that loss of PRC2 or KMT2D-COMPASS enables distinct EMT trajectories, which exert differential effects on the metastatic capability of carcinoma cells.