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Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis

Zhang, Yun; Donaher, Joana Liu; Das, Sunny; Li, Xin; Reinhardt, Ferenc; Krall, Jordan A.; Lambert, Arthur W.; Thiru, Prathapan; Keys, Heather R.; Khan, Mehreen; Hofree, Matan; Wilson, Molly M.; Yedier-Bayram, Ozlem; Lack, Nathan A.; Onder, Tamer T.; Bagci-Onder, Tugba; Tyler, Michael; Tirosh, Itay; Regev, Aviv; Lees, Jacqueline A.; Lees, Jacqueline A.


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{
  "DOI": "10.1038/s41556-022-00877-0", 
  "abstract": "Through genome-wide and focused CRISPR screens, Zhang et al. discover that loss of PRC2 or KMT2D-COMPASS enables distinct EMT trajectories, which exert differential effects on the metastatic capability of carcinoma cells.", 
  "author": [
    {
      "family": "Zhang", 
      "given": " Yun"
    }, 
    {
      "family": "Donaher", 
      "given": " Joana Liu"
    }, 
    {
      "family": "Das", 
      "given": " Sunny"
    }, 
    {
      "family": "Li", 
      "given": " Xin"
    }, 
    {
      "family": "Reinhardt", 
      "given": " Ferenc"
    }, 
    {
      "family": "Krall", 
      "given": " Jordan A."
    }, 
    {
      "family": "Lambert", 
      "given": " Arthur W."
    }, 
    {
      "family": "Thiru", 
      "given": " Prathapan"
    }, 
    {
      "family": "Keys", 
      "given": " Heather R."
    }, 
    {
      "family": "Khan", 
      "given": " Mehreen"
    }, 
    {
      "family": "Hofree", 
      "given": " Matan"
    }, 
    {
      "family": "Wilson", 
      "given": " Molly M."
    }, 
    {
      "family": "Yedier-Bayram", 
      "given": " Ozlem"
    }, 
    {
      "family": "Lack", 
      "given": " Nathan A."
    }, 
    {
      "family": "Onder", 
      "given": " Tamer T."
    }, 
    {
      "family": "Bagci-Onder", 
      "given": " Tugba"
    }, 
    {
      "family": "Tyler", 
      "given": " Michael"
    }, 
    {
      "family": "Tirosh", 
      "given": " Itay"
    }, 
    {
      "family": "Regev", 
      "given": " Aviv"
    }, 
    {
      "family": "Lees", 
      "given": " Jacqueline A."
    }, 
    {
      "family": "Lees", 
      "given": " Jacqueline A."
    }
  ], 
  "container_title": "NATURE CELL BIOLOGY", 
  "id": "259629", 
  "issue": "4", 
  "issued": {
    "date-parts": [
      [
        2022, 
        1, 
        1
      ]
    ]
  }, 
  "page": "554-+", 
  "title": "Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis", 
  "type": "article-journal", 
  "volume": "24"
}
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