Dergi makalesi Açık Erişim
Ekinci, Meliha; Santos-Oliveira, Ralph; Ilem-Ozdemir, Derya
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Santos-Oliveira, Ralph</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Ilem-Ozdemir, Derya</subfield> <subfield code="u">Ege Univ, Fac Pharm, Dept Radiopharm, TR-35040 Izmir, Turkey</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="c">21-31</subfield> <subfield code="p">EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS</subfield> <subfield code="v">176</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="a">Creative Commons Attribution</subfield> <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.1016/j.ejpb.2022.05.006</subfield> <subfield code="2">doi</subfield> </datafield> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Biodistribution of Tc-99m-PLA/PVA/Atezolizumab nanoparticles for non-small cell lung cancer diagnosis</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="a">Ekinci, Meliha</subfield> <subfield code="u">Ege Univ, Fac Pharm, Dept Radiopharm, TR-35040 Izmir, Turkey</subfield> </datafield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:aperta.ulakbim.gov.tr:256299</subfield> <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="2">opendefinition.org</subfield> <subfield code="a">cc-by</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2022-01-01</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="u">https://aperta.ulakbim.gov.trrecord/256299/files/bib-d852cebe-ab32-4027-9ca5-fd01e0e0cb44.txt</subfield> <subfield code="z">md5:0c2d59f31b9ef6917e44802731885c52</subfield> <subfield code="s">235</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <controlfield tag="005">20230729054500.0</controlfield> <controlfield tag="001">256299</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">publication</subfield> <subfield code="b">article</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a">Lung cancer (LC) is a common type of cancer, which is a leading cause of death around the world. There is an urgency for the development of new drugs that could diagnose the LC in the early stages and in a precise manner. In this direction, the development of nanoparticles radiolabeled with the diagnostic radioisotopes represent an important advance in the field of cancer imaging. In this study were developed PLA/PVA/Atezolizumab nano particles which were radiolabeled with 99mTc (Technetium-99m). The radiolabeled nanoparticles were evaluated in both: in-vitro (L-929 and A-549) as in-vivo (mice). The results showed no cytotoxicity effect in the healthy cells (L-929) and cytotoxicity effect in the tumor cells (A-549). The biodistribution assay demonstrated that 99mTc-PLA/PVA/Atezolizumab could reach the tumor site 14-folds higher than the nonparticulate atezolizumab. In conclusion, 99mTc-PLA/PVA/Atezolizumab nanoparticles showed to be a new drug which is able to precisely image the lung tumor, and it must be considered for clinical trials.</subfield> </datafield> </record>
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