1 Ocak 2022 Dergi makalesi Açık Erişim

Ekinci, Meliha; Santos-Oliveira, Ralph; Ilem-Ozdemir, Derya

Dublin Core

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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Ekinci, Meliha</dc:creator>
  <dc:creator>Santos-Oliveira, Ralph</dc:creator>
  <dc:creator>Ilem-Ozdemir, Derya</dc:creator>
  <dc:date>2022-01-01</dc:date>
  <dc:description>Lung cancer (LC) is a common type of cancer, which is a leading cause of death around the world. There is an urgency for the development of new drugs that could diagnose the LC in the early stages and in a precise manner. In this direction, the development of nanoparticles radiolabeled with the diagnostic radioisotopes represent an important advance in the field of cancer imaging. In this study were developed PLA/PVA/Atezolizumab nano particles which were radiolabeled with 99mTc (Technetium-99m). The radiolabeled nanoparticles were evaluated in both: in-vitro (L-929 and A-549) as in-vivo (mice). The results showed no cytotoxicity effect in the healthy cells (L-929) and cytotoxicity effect in the tumor cells (A-549). The biodistribution assay demonstrated that 99mTc-PLA/PVA/Atezolizumab could reach the tumor site 14-folds higher than the nonparticulate atezolizumab. In conclusion, 99mTc-PLA/PVA/Atezolizumab nanoparticles showed to be a new drug which is able to precisely image the lung tumor, and it must be considered for clinical trials.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/256299</dc:identifier>
  <dc:identifier>oai:aperta.ulakbim.gov.tr:256299</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 176 21-31</dc:source>
  <dc:title>Biodistribution of Tc-99m-PLA/PVA/Atezolizumab nanoparticles for non-small cell lung cancer diagnosis</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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