1 Ocak 2022 Dergi makalesi Açık Erişim

Ekinci, Meliha; Santos-Oliveira, Ralph; Ilem-Ozdemir, Derya

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        "affiliation": "Ege Univ, Fac Pharm, Dept Radiopharm, TR-35040 Izmir, Turkey", 
        "name": "Ekinci, Meliha"
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      {
        "name": "Santos-Oliveira, Ralph"
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        "affiliation": "Ege Univ, Fac Pharm, Dept Radiopharm, TR-35040 Izmir, Turkey", 
        "name": "Ilem-Ozdemir, Derya"
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    "description": "Lung cancer (LC) is a common type of cancer, which is a leading cause of death around the world. There is an urgency for the development of new drugs that could diagnose the LC in the early stages and in a precise manner. In this direction, the development of nanoparticles radiolabeled with the diagnostic radioisotopes represent an important advance in the field of cancer imaging. In this study were developed PLA/PVA/Atezolizumab nano particles which were radiolabeled with 99mTc (Technetium-99m). The radiolabeled nanoparticles were evaluated in both: in-vitro (L-929 and A-549) as in-vivo (mice). The results showed no cytotoxicity effect in the healthy cells (L-929) and cytotoxicity effect in the tumor cells (A-549). The biodistribution assay demonstrated that 99mTc-PLA/PVA/Atezolizumab could reach the tumor site 14-folds higher than the nonparticulate atezolizumab. In conclusion, 99mTc-PLA/PVA/Atezolizumab nanoparticles showed to be a new drug which is able to precisely image the lung tumor, and it must be considered for clinical trials.", 
    "doi": "10.1016/j.ejpb.2022.05.006", 
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    "journal": {
      "pages": "21-31", 
      "title": "EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS", 
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    "title": "Biodistribution of Tc-99m-PLA/PVA/Atezolizumab nanoparticles for non-small cell lung cancer diagnosis"
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