1 Ocak 2022 Dergi makalesi Açık Erişim

Ekinci, Meliha; Santos-Oliveira, Ralph; Ilem-Ozdemir, Derya

Citation Style Language JSON

{
  "DOI": "10.1016/j.ejpb.2022.05.006", 
  "abstract": "Lung cancer (LC) is a common type of cancer, which is a leading cause of death around the world. There is an urgency for the development of new drugs that could diagnose the LC in the early stages and in a precise manner. In this direction, the development of nanoparticles radiolabeled with the diagnostic radioisotopes represent an important advance in the field of cancer imaging. In this study were developed PLA/PVA/Atezolizumab nano particles which were radiolabeled with 99mTc (Technetium-99m). The radiolabeled nanoparticles were evaluated in both: in-vitro (L-929 and A-549) as in-vivo (mice). The results showed no cytotoxicity effect in the healthy cells (L-929) and cytotoxicity effect in the tumor cells (A-549). The biodistribution assay demonstrated that 99mTc-PLA/PVA/Atezolizumab could reach the tumor site 14-folds higher than the nonparticulate atezolizumab. In conclusion, 99mTc-PLA/PVA/Atezolizumab nanoparticles showed to be a new drug which is able to precisely image the lung tumor, and it must be considered for clinical trials.", 
  "author": [
    {
      "family": "Ekinci", 
      "given": " Meliha"
    }, 
    {
      "family": "Santos-Oliveira", 
      "given": " Ralph"
    }, 
    {
      "family": "Ilem-Ozdemir", 
      "given": " Derya"
    }
  ], 
  "container_title": "EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS", 
  "id": "256299", 
  "issued": {
    "date-parts": [
      [
        2022, 
        1, 
        1
      ]
    ]
  }, 
  "page": "21-31", 
  "title": "Biodistribution of Tc-99m-PLA/PVA/Atezolizumab nanoparticles for non-small cell lung cancer diagnosis", 
  "type": "article-journal", 
  "volume": "176"
}