1 Ocak 2010 Dergi makalesi Açık Erişim

Aydemir-Koksoy, Aslihan; Bilginoglu, Ayca; Sariahmetoglu, Meltem; Schulz, Richard; Turan, Belma

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Antioxidant treatment protects diabetic rats from cardiac dysfunction by preserving contractile protein targets of oxidative stress</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="p">JOURNAL OF NUTRITIONAL BIOCHEMISTRY</subfield>
    <subfield code="v">21</subfield>
    <subfield code="n">9</subfield>
    <subfield code="c">827-833</subfield>
  </datafield>
  <controlfield tag="001">25205</controlfield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">Backgound Animal studies suggest that reactive oxygen species (ROS) play an important role in the development of diabetic cardiomyopathy. Hypothesis. Matrix metalloproteinase-2 (MMP-2) is activated by ROS and contributes to the acute loss of myocardial contractile function by targeting and cleaving susceptible proteins including troponin I (Inc) and alpha-actinin. Methods Using the streptozotocin-induced diabetic rat model, we evaluated the effect of daily in vivo administration of sodium selenate (0 3 mg/kg; DMS group), or a pure omega-3 fish oil with antioxidant vitamin E (omega-3E, 50 mg/kg. DMFA group), which has antioxidant-like effects, for 4 weeks on heart function and on several biochemical parameters related to oxidant stress and MMP-2. Results. Although both treatments prevented the diabetes-induced depression in left ventricular developed pressure (LVDP) as well as the rates of changes in developed pressure (+/-dP/dt) (P&amp;lt;.001), the improvement in LVDP of the DMS group was greater compared to that of the DMFA group (P&amp;lt;.001). Moreover, these treatments reduced the diabetes-induced increase in myocardial oxidized protein sulfhydryl and nitrite concentrations (P&amp;lt;.001). Gelatin zymography and Western blot data indicated that the diabetes-induced changes in myocardial levels of MMP-2 and tissue inhibitor of matrix metalloproteinase-4 (TIMP-4) and the reduction in TnI and alpha-actinin protein levels were improved in both the DMS and DMFA groups (P&amp;lt;.001). Conclusions: These results suggest that diabetes-induced alterations in MMP-2 and TIMP-4 contribute to myocardial contractile dysfunction by targeting TnI and alpha-actinin and that sodium selenate or omega-3E could have therapeutic benefits in diabetic cardiomyopathy. (C) 2010 Elsevier Inc. All rights reserved.</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="2">opendefinition.org</subfield>
    <subfield code="a">cc-by</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Ankara Univ, Dept Biophys, Fac Med, TR-06100 Ankara, Turkey</subfield>
    <subfield code="a">Bilginoglu, Ayca</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Sariahmetoglu, Meltem</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Schulz, Richard</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Ankara Univ, Dept Biophys, Fac Med, TR-06100 Ankara, Turkey</subfield>
    <subfield code="a">Turan, Belma</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="b">article</subfield>
    <subfield code="a">publication</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="u">Ankara Univ, Dept Biophys, Fac Med, TR-06100 Ankara, Turkey</subfield>
    <subfield code="a">Aydemir-Koksoy, Aslihan</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2010-01-01</subfield>
  </datafield>
  <controlfield tag="005">20210315113900.0</controlfield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="o">oai:zenodo.org:25205</subfield>
    <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="z">md5:379cca23390e6332fcc630a17c0e180f</subfield>
    <subfield code="s">271</subfield>
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/25205/files/bib-6e0d3559-22d0-4d63-902c-f3c42e4467cc.txt</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield>
    <subfield code="a">Creative Commons Attribution</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.1016/j.jnutbio.2009.06.006</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
</record>