1 Ocak 2010 Dergi makalesi Açık Erişim

Aydemir-Koksoy, Aslihan; Bilginoglu, Ayca; Sariahmetoglu, Meltem; Schulz, Richard; Turan, Belma

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  <dc:creator>Aydemir-Koksoy, Aslihan</dc:creator>
  <dc:creator>Bilginoglu, Ayca</dc:creator>
  <dc:creator>Sariahmetoglu, Meltem</dc:creator>
  <dc:creator>Schulz, Richard</dc:creator>
  <dc:creator>Turan, Belma</dc:creator>
  <dc:date>2010-01-01</dc:date>
  <dc:description>Backgound Animal studies suggest that reactive oxygen species (ROS) play an important role in the development of diabetic cardiomyopathy. Hypothesis. Matrix metalloproteinase-2 (MMP-2) is activated by ROS and contributes to the acute loss of myocardial contractile function by targeting and cleaving susceptible proteins including troponin I (Inc) and alpha-actinin. Methods Using the streptozotocin-induced diabetic rat model, we evaluated the effect of daily in vivo administration of sodium selenate (0 3 mg/kg; DMS group), or a pure omega-3 fish oil with antioxidant vitamin E (omega-3E, 50 mg/kg. DMFA group), which has antioxidant-like effects, for 4 weeks on heart function and on several biochemical parameters related to oxidant stress and MMP-2. Results. Although both treatments prevented the diabetes-induced depression in left ventricular developed pressure (LVDP) as well as the rates of changes in developed pressure (+/-dP/dt) (P&lt;.001), the improvement in LVDP of the DMS group was greater compared to that of the DMFA group (P&lt;.001). Moreover, these treatments reduced the diabetes-induced increase in myocardial oxidized protein sulfhydryl and nitrite concentrations (P&lt;.001). Gelatin zymography and Western blot data indicated that the diabetes-induced changes in myocardial levels of MMP-2 and tissue inhibitor of matrix metalloproteinase-4 (TIMP-4) and the reduction in TnI and alpha-actinin protein levels were improved in both the DMS and DMFA groups (P&lt;.001). Conclusions: These results suggest that diabetes-induced alterations in MMP-2 and TIMP-4 contribute to myocardial contractile dysfunction by targeting TnI and alpha-actinin and that sodium selenate or omega-3E could have therapeutic benefits in diabetic cardiomyopathy. (C) 2010 Elsevier Inc. All rights reserved.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/25205</dc:identifier>
  <dc:identifier>oai:zenodo.org:25205</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>JOURNAL OF NUTRITIONAL BIOCHEMISTRY 21(9) 827-833</dc:source>
  <dc:title>Antioxidant treatment protects diabetic rats from cardiac dysfunction by preserving contractile protein targets of oxidative stress</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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