1 Ocak 2010 Dergi makalesi Açık Erişim

Aydemir-Koksoy, Aslihan; Bilginoglu, Ayca; Sariahmetoglu, Meltem; Schulz, Richard; Turan, Belma

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        "affiliation": "Ankara Univ, Dept Biophys, Fac Med, TR-06100 Ankara, Turkey", 
        "name": "Aydemir-Koksoy, Aslihan"
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      {
        "affiliation": "Ankara Univ, Dept Biophys, Fac Med, TR-06100 Ankara, Turkey", 
        "name": "Bilginoglu, Ayca"
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      {
        "name": "Sariahmetoglu, Meltem"
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      {
        "name": "Schulz, Richard"
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      {
        "affiliation": "Ankara Univ, Dept Biophys, Fac Med, TR-06100 Ankara, Turkey", 
        "name": "Turan, Belma"
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    "description": "Backgound Animal studies suggest that reactive oxygen species (ROS) play an important role in the development of diabetic cardiomyopathy. Hypothesis. Matrix metalloproteinase-2 (MMP-2) is activated by ROS and contributes to the acute loss of myocardial contractile function by targeting and cleaving susceptible proteins including troponin I (Inc) and alpha-actinin. Methods Using the streptozotocin-induced diabetic rat model, we evaluated the effect of daily in vivo administration of sodium selenate (0 3 mg/kg; DMS group), or a pure omega-3 fish oil with antioxidant vitamin E (omega-3E, 50 mg/kg. DMFA group), which has antioxidant-like effects, for 4 weeks on heart function and on several biochemical parameters related to oxidant stress and MMP-2. Results. Although both treatments prevented the diabetes-induced depression in left ventricular developed pressure (LVDP) as well as the rates of changes in developed pressure (+/-dP/dt) (P<.001), the improvement in LVDP of the DMS group was greater compared to that of the DMFA group (P<.001). Moreover, these treatments reduced the diabetes-induced increase in myocardial oxidized protein sulfhydryl and nitrite concentrations (P<.001). Gelatin zymography and Western blot data indicated that the diabetes-induced changes in myocardial levels of MMP-2 and tissue inhibitor of matrix metalloproteinase-4 (TIMP-4) and the reduction in TnI and alpha-actinin protein levels were improved in both the DMS and DMFA groups (P<.001). Conclusions: These results suggest that diabetes-induced alterations in MMP-2 and TIMP-4 contribute to myocardial contractile dysfunction by targeting TnI and alpha-actinin and that sodium selenate or omega-3E could have therapeutic benefits in diabetic cardiomyopathy. (C) 2010 Elsevier Inc. All rights reserved.", 
    "doi": "10.1016/j.jnutbio.2009.06.006", 
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    "journal": {
      "issue": "9", 
      "pages": "827-833", 
      "title": "JOURNAL OF NUTRITIONAL BIOCHEMISTRY", 
      "volume": "21"
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    "publication_date": "2010-01-01", 
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    "title": "Antioxidant treatment protects diabetic rats from cardiac dysfunction by preserving contractile protein targets of oxidative stress"
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