1 Ocak 2010 Dergi makalesi Açık Erişim

Aydemir-Koksoy, Aslihan; Bilginoglu, Ayca; Sariahmetoglu, Meltem; Schulz, Richard; Turan, Belma

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{
  "DOI": "10.1016/j.jnutbio.2009.06.006", 
  "abstract": "Backgound Animal studies suggest that reactive oxygen species (ROS) play an important role in the development of diabetic cardiomyopathy. Hypothesis. Matrix metalloproteinase-2 (MMP-2) is activated by ROS and contributes to the acute loss of myocardial contractile function by targeting and cleaving susceptible proteins including troponin I (Inc) and alpha-actinin. Methods Using the streptozotocin-induced diabetic rat model, we evaluated the effect of daily in vivo administration of sodium selenate (0 3 mg/kg; DMS group), or a pure omega-3 fish oil with antioxidant vitamin E (omega-3E, 50 mg/kg. DMFA group), which has antioxidant-like effects, for 4 weeks on heart function and on several biochemical parameters related to oxidant stress and MMP-2. Results. Although both treatments prevented the diabetes-induced depression in left ventricular developed pressure (LVDP) as well as the rates of changes in developed pressure (+/-dP/dt) (P<.001), the improvement in LVDP of the DMS group was greater compared to that of the DMFA group (P<.001). Moreover, these treatments reduced the diabetes-induced increase in myocardial oxidized protein sulfhydryl and nitrite concentrations (P<.001). Gelatin zymography and Western blot data indicated that the diabetes-induced changes in myocardial levels of MMP-2 and tissue inhibitor of matrix metalloproteinase-4 (TIMP-4) and the reduction in TnI and alpha-actinin protein levels were improved in both the DMS and DMFA groups (P<.001). Conclusions: These results suggest that diabetes-induced alterations in MMP-2 and TIMP-4 contribute to myocardial contractile dysfunction by targeting TnI and alpha-actinin and that sodium selenate or omega-3E could have therapeutic benefits in diabetic cardiomyopathy. (C) 2010 Elsevier Inc. All rights reserved.", 
  "author": [
    {
      "family": "Aydemir-Koksoy", 
      "given": " Aslihan"
    }, 
    {
      "family": "Bilginoglu", 
      "given": " Ayca"
    }, 
    {
      "family": "Sariahmetoglu", 
      "given": " Meltem"
    }, 
    {
      "family": "Schulz", 
      "given": " Richard"
    }, 
    {
      "family": "Turan", 
      "given": " Belma"
    }
  ], 
  "container_title": "JOURNAL OF NUTRITIONAL BIOCHEMISTRY", 
  "id": "25205", 
  "issue": "9", 
  "issued": {
    "date-parts": [
      [
        2010, 
        1, 
        1
      ]
    ]
  }, 
  "page": "827-833", 
  "title": "Antioxidant treatment protects diabetic rats from cardiac dysfunction by preserving contractile protein targets of oxidative stress", 
  "type": "article-journal", 
  "volume": "21"
}