1 Ocak 2021 Dergi makalesi Açık Erişim

Akin, Senay; Kubat, Gokhan B.; Guray, Umit; Akin, Yesim; Demirel, Haydar A.

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{
  "@context": "https://schema.org/", 
  "@id": 236452, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Fac Sport Sci, Dept Exercise & Sport Physiol, Ankara, Turkey", 
      "name": "Akin, Senay"
    }, 
    {
      "@type": "Person", 
      "name": "Kubat, Gokhan B."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ankara City Hosp, Dept Cardiol, Ankara, Turkey", 
      "name": "Guray, Umit"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Karabuk Univ, Dept Cardiol, Fac Med, Karabuk, Turkey", 
      "name": "Akin, Yesim"
    }, 
    {
      "@type": "Person", 
      "name": "Demirel, Haydar A."
    }
  ], 
  "datePublished": "2021-01-01", 
  "description": "Glucocorticoids are among the most prescribed drugs globally due to their potent anti-inflammatory and immunosuppressive properties. Although they have positive effects on the treatment of various disease states; long-term administration is associated with high blood pressure, insulin resistance, and susceptibility to type 2 diabetes. The heart attempts to cope with increased blood pressure and a decrease in glucose utilization by developing pathological cardiac remodeling. However, in this process, cardiac fibrosis formation and deterioration in heart structure and functions occur. Galectin-3, a member of the beta-galactoside binding lectins, is consistently associated with inflammation and fibrosis in the pathogenesis of various disease states including insulin resistance and heart failure. Galectin-3 expression is markedly increased in activated macrophages and a subset of activated fibroblasts and vascular cells. Also, failing and remodeling myocardium show increased Gal-3 expression and elevated Gal-3 levels are related to heart failure severity and prognosis. Furthermore, Gal-3-related pathways are recently suggested as therapeutic targets both pharmacologically and genetically to increase insulin sensitivity in vivo. The objective of this review is to provide a summary of our current understanding of the role of glucocorticoid-associated insulin resistance, which is important for some cardiac events, and the potential role of galectin in this pathophysiological process.", 
  "headline": "Possible value of galectin-3 on follow-up of cardiac remodeling during glucocorticoid treatment", 
  "identifier": 236452, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Possible value of galectin-3 on follow-up of cardiac remodeling during glucocorticoid treatment", 
  "url": "https://aperta.ulakbim.gov.tr/record/236452"
}