1 Ocak 2021 Dergi makalesi Açık Erişim

Akin, Senay; Kubat, Gokhan B.; Guray, Umit; Akin, Yesim; Demirel, Haydar A.

DataCite XML

<?xml version='1.0' encoding='utf-8'?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd">
  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/236452</identifier>
  <creators>
    <creator>
      <creatorName>Akin, Senay</creatorName>
      <givenName>Senay</givenName>
      <familyName>Akin</familyName>
      <affiliation>Hacettepe Univ, Fac Sport Sci, Dept Exercise &amp; Sport Physiol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kubat, Gokhan B.</creatorName>
      <givenName>Gokhan B.</givenName>
      <familyName>Kubat</familyName>
    </creator>
    <creator>
      <creatorName>Guray, Umit</creatorName>
      <givenName>Umit</givenName>
      <familyName>Guray</familyName>
      <affiliation>Ankara City Hosp, Dept Cardiol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akin, Yesim</creatorName>
      <givenName>Yesim</givenName>
      <familyName>Akin</familyName>
      <affiliation>Karabuk Univ, Dept Cardiol, Fac Med, Karabuk, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Demirel, Haydar A.</creatorName>
      <givenName>Haydar A.</givenName>
      <familyName>Demirel</familyName>
    </creator>
  </creators>
  <titles>
    <title>Possible Value Of Galectin-3 On Follow-Up Of Cardiac Remodeling During Glucocorticoid Treatment</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/236452</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1002/jbt.22717</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Glucocorticoids are among the most prescribed drugs globally due to their potent anti-inflammatory and immunosuppressive properties. Although they have positive effects on the treatment of various disease states; long-term administration is associated with high blood pressure, insulin resistance, and susceptibility to type 2 diabetes. The heart attempts to cope with increased blood pressure and a decrease in glucose utilization by developing pathological cardiac remodeling. However, in this process, cardiac fibrosis formation and deterioration in heart structure and functions occur. Galectin-3, a member of the beta-galactoside binding lectins, is consistently associated with inflammation and fibrosis in the pathogenesis of various disease states including insulin resistance and heart failure. Galectin-3 expression is markedly increased in activated macrophages and a subset of activated fibroblasts and vascular cells. Also, failing and remodeling myocardium show increased Gal-3 expression and elevated Gal-3 levels are related to heart failure severity and prognosis. Furthermore, Gal-3-related pathways are recently suggested as therapeutic targets both pharmacologically and genetically to increase insulin sensitivity in vivo. The objective of this review is to provide a summary of our current understanding of the role of glucocorticoid-associated insulin resistance, which is important for some cardiac events, and the potential role of galectin in this pathophysiological process.</description>
  </descriptions>
</resource>