1 Ocak 2021 Dergi makalesi Açık Erişim

Akin, Senay; Kubat, Gokhan B.; Guray, Umit; Akin, Yesim; Demirel, Haydar A.

Citation Style Language JSON

{
  "DOI": "10.1002/jbt.22717", 
  "abstract": "Glucocorticoids are among the most prescribed drugs globally due to their potent anti-inflammatory and immunosuppressive properties. Although they have positive effects on the treatment of various disease states; long-term administration is associated with high blood pressure, insulin resistance, and susceptibility to type 2 diabetes. The heart attempts to cope with increased blood pressure and a decrease in glucose utilization by developing pathological cardiac remodeling. However, in this process, cardiac fibrosis formation and deterioration in heart structure and functions occur. Galectin-3, a member of the beta-galactoside binding lectins, is consistently associated with inflammation and fibrosis in the pathogenesis of various disease states including insulin resistance and heart failure. Galectin-3 expression is markedly increased in activated macrophages and a subset of activated fibroblasts and vascular cells. Also, failing and remodeling myocardium show increased Gal-3 expression and elevated Gal-3 levels are related to heart failure severity and prognosis. Furthermore, Gal-3-related pathways are recently suggested as therapeutic targets both pharmacologically and genetically to increase insulin sensitivity in vivo. The objective of this review is to provide a summary of our current understanding of the role of glucocorticoid-associated insulin resistance, which is important for some cardiac events, and the potential role of galectin in this pathophysiological process.", 
  "author": [
    {
      "family": "Akin", 
      "given": " Senay"
    }, 
    {
      "family": "Kubat", 
      "given": " Gokhan B."
    }, 
    {
      "family": "Guray", 
      "given": " Umit"
    }, 
    {
      "family": "Akin", 
      "given": " Yesim"
    }, 
    {
      "family": "Demirel", 
      "given": " Haydar A."
    }
  ], 
  "container_title": "JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY", 
  "id": "236452", 
  "issue": "4", 
  "issued": {
    "date-parts": [
      [
        2021, 
        1, 
        1
      ]
    ]
  }, 
  "title": "Possible value of galectin-3 on follow-up of cardiac remodeling during glucocorticoid treatment", 
  "type": "article-journal", 
  "volume": "35"
}