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Effect of dietary nano-selenium on stress indicators, immune response, and DNA damage in broiler subjected to different stocking density

Sevim, O.; Ahsan, U.; Tatli, O.; Kuter, E.; Khamseh, E. Karimiyan; Temiz, A. Reman; Ozdemir, O. Sayin; Aydin, A. K.; Sahiner, H. S.; Avcioglu, M.; Yildirim, E. Koc


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    "creators": [
      {
        "affiliation": "Adnan Menderes Univ, Fac Vet Med, Dept Anim Nutr & Nutr Dis, TR-09016 Aydin, Turkey", 
        "name": "Sevim, O."
      }, 
      {
        "affiliation": "Burdur Mehmet Akif Ersoy Univ, Dept Plant & Anim Prod, Burdur Vocat Sch Food Agr & Livestock, Istiklal Campus, TR-15030 Burdur, Turkey", 
        "name": "Ahsan, U."
      }, 
      {
        "affiliation": "Adnan Menderes Univ, Fac Vet Med, Dept Anim Nutr & Nutr Dis, TR-09016 Aydin, Turkey", 
        "name": "Tatli, O."
      }, 
      {
        "affiliation": "Burdur Mehmet Akif Ersoy Univ, Fac Vet Med, Dept Anim Nutr & Nutr Dis, Istiklal Campus, TR-15030 Burdur, Turkey", 
        "name": "Kuter, E."
      }, 
      {
        "affiliation": "Adnan Menderes Univ, Fac Vet Med, Dept Anim Nutr & Nutr Dis, TR-09016 Aydin, Turkey", 
        "name": "Khamseh, E. Karimiyan"
      }, 
      {
        "affiliation": "Adnan Menderes Univ, Fac Vet Med, Dept Anim Nutr & Nutr Dis, TR-09016 Aydin, Turkey", 
        "name": "Temiz, A. Reman"
      }, 
      {
        "affiliation": "Adnan Menderes Univ, Fac Vet Med, Dept Anim Nutr & Nutr Dis, TR-09016 Aydin, Turkey", 
        "name": "Ozdemir, O. Sayin"
      }, 
      {
        "affiliation": "Adnan Menderes Univ, Fac Vet Med, Dept Anim Nutr & Nutr Dis, TR-09016 Aydin, Turkey", 
        "name": "Aydin, A. K."
      }, 
      {
        "affiliation": "Adnan Menderes Univ, Fac Vet Med, Dept Pharmacol & Toxicol, TR-09016 Aydin, Turkey", 
        "name": "Sahiner, H. S."
      }, 
      {
        "affiliation": "Adnan Menderes Univ, Fac Vet Med, Dept Pharmacol & Toxicol, TR-09016 Aydin, Turkey", 
        "name": "Avcioglu, M."
      }, 
      {
        "affiliation": "Adnan Menderes Univ, Fac Vet Med, Dept Physiol, TR-09016 Aydin, Turkey", 
        "name": "Yildirim, E. Koc"
      }
    ], 
    "description": "In the present study, we examined the effect of nano-selenium (nano-Se) and stocking density (SD) on antioxidant status, immune response, and DNA damage in broiler chickens. A total of 480 one-d-old male broilers (Ross 308) were randomly divided into 4 treatments each including 8 replicates for 42 days. A 2 x 2 factorial arrangement of groups for two dietary selenium forms (inorganic or nano) and two stocking densities [low = 12 birds/m(2) (LSD) and high = 18 birds/m(2) (HSD)] was conducted. Starter, grower, and finisher diets were formulated based on corn-soybean meal according to recommendations of Aviagen. There were no significant differences in the lymphoid organ index due to high stocking density or nano-Se. Neither HSD nor dietary nano-Se had an effect on blood heterophil: lymphocyte ratio, serum corticosterone, glutathione, superoxide dismutase, and malondialdehyde levels. Serum interferon-gamma, interleukin 12, and interleukin 18 levels were not affected either by HSD or by dietary nano-Se. However, an interaction was witnessed between SD and dietary Se form for serum interferon-gamma (P < 0.05). HSD increased the DNA damage in lymphocyte (P < 0.05), but dietary nano-Se had no significant effect on it. In conclusion, HSD and dietary nano-Se may not affect the organ index, stress indicators, and immune function, but dietary nano-Se decreased the possible negative effect of HSD on serum interferon-gamma. HSD increased the DNA damage but dietary nano-Se had no effect.", 
    "doi": "10.1399/eps.2021.345", 
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    "journal": {
      "pages": "1-13", 
      "title": "EUROPEAN POULTRY SCIENCE", 
      "volume": "85"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2021-01-01", 
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    "title": "Effect of dietary nano-selenium on stress indicators, immune response, and DNA damage in broiler subjected to different stocking density"
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