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Synthesis of alpha-Alkylated Ketones via Selective Epoxide Opening/Alkylation Reactions with Primary Alcohols

Genc, Sertac; Gulcemal, Suleyman; Gunnaz, Salih; Cetinkaya, Bekir; Gulcemal, Derya


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{
  "DOI": "10.1021/acs.orglett.1c01765", 
  "abstract": "A new method for converting terminal epoxides and primary alcohols into alpha-alkylated ketones under borrowing hydrogen conditions is reported. The procedure involves a one-pot epoxide ring opening and alkylation via primary alcohols in the presence of an N-heterocyclic carbene iridium(I) catalyst, under aerobic conditions, with water as the side product.", 
  "author": [
    {
      "family": "Genc", 
      "given": " Sertac"
    }, 
    {
      "family": "Gulcemal", 
      "given": " Suleyman"
    }, 
    {
      "family": "Gunnaz", 
      "given": " Salih"
    }, 
    {
      "family": "Cetinkaya", 
      "given": " Bekir"
    }, 
    {
      "family": "Gulcemal", 
      "given": " Derya"
    }
  ], 
  "container_title": "ORGANIC LETTERS", 
  "id": "234854", 
  "issue": "13", 
  "issued": {
    "date-parts": [
      [
        2021, 
        1, 
        1
      ]
    ]
  }, 
  "page": "5229-5234", 
  "title": "Synthesis of alpha-Alkylated Ketones via Selective Epoxide Opening/Alkylation Reactions with Primary Alcohols", 
  "type": "article-journal", 
  "volume": "23"
}
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