1 Ocak 2021 Dergi makalesi Açık Erişim

Karakus, Gozde Sir; Tastan, Cihan; Kancagi, Derya Dilek; Yurtsever, Bulut; Tumentemur, Gamze; Demir, Sevda; Turan, Raife Dilek; Abanuz, Selen; Cakirsoy, Didem; Seyis, Utku; Ozer, Samed; Elibol, Omer; Elek, Muhammer; Ertop, Gurcan; Arbale, Serap; Elmas, Merve Acikel; Hermsinlioglu, Canso; Kocagoz, Ayse Sesin; Ng, Ozden Hatirnaz; Akyoney, Sezer; Akyoney, Sezer

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  "@context": "https://schema.org/", 
  "@id": 231896, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey", 
      "name": "Karakus, Gozde Sir"
    }, 
    {
      "@type": "Person", 
      "name": "Tastan, Cihan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey", 
      "name": "Kancagi, Derya Dilek"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey", 
      "name": "Yurtsever, Bulut"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Vocat Sch Hlth Serv, Istanbul, Turkey", 
      "name": "Tumentemur, Gamze"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Yeditepe Univ, Genet & Bioengn Dept, Istanbul, Turkey", 
      "name": "Demir, Sevda"
    }, 
    {
      "@type": "Person", 
      "name": "Turan, Raife Dilek"
    }, 
    {
      "@type": "Person", 
      "name": "Abanuz, Selen"
    }, 
    {
      "@type": "Person", 
      "name": "Cakirsoy, Didem"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey", 
      "name": "Seyis, Utku"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Anim Applicat & Res Ctr, Istanbul, Turkey", 
      "name": "Ozer, Samed"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Acibadem Altunizade Hosp, Istanbul, Turkey", 
      "name": "Elibol, Omer"
    }, 
    {
      "@type": "Person", 
      "name": "Elek, Muhammer"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Vocat Sch Hlth Serv, Istanbul, Turkey", 
      "name": "Ertop, Gurcan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Histol & Embryol Dept, Istanbul, Turkey", 
      "name": "Arbale, Serap"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Histol & Embryol Dept, Istanbul, Turkey", 
      "name": "Elmas, Merve Acikel"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey", 
      "name": "Hermsinlioglu, Canso"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Acibadem Altunizade Hosp, Infect Dis Unit, Istanbul, Turkey", 
      "name": "Kocagoz, Ayse Sesin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Med Biol Dept, Istanbul, Turkey", 
      "name": "Ng, Ozden Hatirnaz"
    }, 
    {
      "@type": "Person", 
      "name": "Akyoney, Sezer"
    }, 
    {
      "@type": "Person", 
      "name": "Akyoney, Sezer"
    }
  ], 
  "datePublished": "2021-01-01", 
  "description": "COVID-19 outbreak caused by SARS-CoV-2 created an unprecedented health crisis since there is no vaccine for this novel virus. Therefore, SARS-CoV-2 vaccines have become crucial for reducing morbidity and mortality. In this study, in vitro and in vivo safety and efficacy analyzes of lyophilized vaccine candidates inactivated by gamma-irradiation were performed. The candidate vaccines in this study were OZG-3861 version 1(V1), an inactivated SARS-CoV-2 virus vaccine, and SK-01 version 1 (V1), a GM-CSF adjuvant added vaccine. The candidate vaccines were applied intradermally to BALB/c mice to assess toxicity and immunogenicity. Preliminary results in vaccinated mice are reported in this study. Especially, the vaccine models containing GM-CSF caused significant antibody production with neutralization capacity in absence of the antibody-dependent enhancement feature, when considered in terms of T and B cell responses. Another important finding was that the presence of adjuvant was more important in T cell in comparison with B cell response. Vaccinated mice showed T cell response upon restimulation with whole inactivated SARS-CoV-2 or peptide pool. This study shows that the vaccines are effective and leads us to start the challenge test to investigate the gamma-irradiated inactivated vaccine candidates for infective SARS-CoV-2 virus in humanized ACE2+ mice.", 
  "headline": "Preclinical efficacy and safety analysis of gamma-irradiated inactivated SARS-CoV-2 vaccine candidates", 
  "identifier": 231896, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Preclinical efficacy and safety analysis of gamma-irradiated inactivated SARS-CoV-2 vaccine candidates", 
  "url": "https://aperta.ulakbim.gov.tr/record/231896"
}