1 Ocak 2021 Dergi makalesi Açık Erişim

Karakus, Gozde Sir; Tastan, Cihan; Kancagi, Derya Dilek; Yurtsever, Bulut; Tumentemur, Gamze; Demir, Sevda; Turan, Raife Dilek; Abanuz, Selen; Cakirsoy, Didem; Seyis, Utku; Ozer, Samed; Elibol, Omer; Elek, Muhammer; Ertop, Gurcan; Arbale, Serap; Elmas, Merve Acikel; Hermsinlioglu, Canso; Kocagoz, Ayse Sesin; Ng, Ozden Hatirnaz; Akyoney, Sezer; Akyoney, Sezer

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{
  "DOI": "10.1038/s41598-021-83930-6", 
  "abstract": "COVID-19 outbreak caused by SARS-CoV-2 created an unprecedented health crisis since there is no vaccine for this novel virus. Therefore, SARS-CoV-2 vaccines have become crucial for reducing morbidity and mortality. In this study, in vitro and in vivo safety and efficacy analyzes of lyophilized vaccine candidates inactivated by gamma-irradiation were performed. The candidate vaccines in this study were OZG-3861 version 1(V1), an inactivated SARS-CoV-2 virus vaccine, and SK-01 version 1 (V1), a GM-CSF adjuvant added vaccine. The candidate vaccines were applied intradermally to BALB/c mice to assess toxicity and immunogenicity. Preliminary results in vaccinated mice are reported in this study. Especially, the vaccine models containing GM-CSF caused significant antibody production with neutralization capacity in absence of the antibody-dependent enhancement feature, when considered in terms of T and B cell responses. Another important finding was that the presence of adjuvant was more important in T cell in comparison with B cell response. Vaccinated mice showed T cell response upon restimulation with whole inactivated SARS-CoV-2 or peptide pool. This study shows that the vaccines are effective and leads us to start the challenge test to investigate the gamma-irradiated inactivated vaccine candidates for infective SARS-CoV-2 virus in humanized ACE2+ mice.", 
  "author": [
    {
      "family": "Karakus", 
      "given": " Gozde Sir"
    }, 
    {
      "family": "Tastan", 
      "given": " Cihan"
    }, 
    {
      "family": "Kancagi", 
      "given": " Derya Dilek"
    }, 
    {
      "family": "Yurtsever", 
      "given": " Bulut"
    }, 
    {
      "family": "Tumentemur", 
      "given": " Gamze"
    }, 
    {
      "family": "Demir", 
      "given": " Sevda"
    }, 
    {
      "family": "Turan", 
      "given": " Raife Dilek"
    }, 
    {
      "family": "Abanuz", 
      "given": " Selen"
    }, 
    {
      "family": "Cakirsoy", 
      "given": " Didem"
    }, 
    {
      "family": "Seyis", 
      "given": " Utku"
    }, 
    {
      "family": "Ozer", 
      "given": " Samed"
    }, 
    {
      "family": "Elibol", 
      "given": " Omer"
    }, 
    {
      "family": "Elek", 
      "given": " Muhammer"
    }, 
    {
      "family": "Ertop", 
      "given": " Gurcan"
    }, 
    {
      "family": "Arbale", 
      "given": " Serap"
    }, 
    {
      "family": "Elmas", 
      "given": " Merve Acikel"
    }, 
    {
      "family": "Hermsinlioglu", 
      "given": " Canso"
    }, 
    {
      "family": "Kocagoz", 
      "given": " Ayse Sesin"
    }, 
    {
      "family": "Ng", 
      "given": " Ozden Hatirnaz"
    }, 
    {
      "family": "Akyoney", 
      "given": " Sezer"
    }, 
    {
      "family": "Akyoney", 
      "given": " Sezer"
    }
  ], 
  "container_title": "SCIENTIFIC REPORTS", 
  "id": "231896", 
  "issue": "1", 
  "issued": {
    "date-parts": [
      [
        2021, 
        1, 
        1
      ]
    ]
  }, 
  "title": "Preclinical efficacy and safety analysis of gamma-irradiated inactivated SARS-CoV-2 vaccine candidates", 
  "type": "article-journal", 
  "volume": "11"
}