1 Ocak 2021 Dergi makalesi Açık Erişim

Karakus, Gozde Sir; Tastan, Cihan; Kancagi, Derya Dilek; Yurtsever, Bulut; Tumentemur, Gamze; Demir, Sevda; Turan, Raife Dilek; Abanuz, Selen; Cakirsoy, Didem; Seyis, Utku; Ozer, Samed; Elibol, Omer; Elek, Muhammer; Ertop, Gurcan; Arbale, Serap; Elmas, Merve Acikel; Hermsinlioglu, Canso; Kocagoz, Ayse Sesin; Ng, Ozden Hatirnaz; Akyoney, Sezer; Akyoney, Sezer

JSON

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        "affiliation": "Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey", 
        "name": "Karakus, Gozde Sir"
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      {
        "name": "Tastan, Cihan"
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      {
        "affiliation": "Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey", 
        "name": "Kancagi, Derya Dilek"
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      {
        "affiliation": "Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey", 
        "name": "Yurtsever, Bulut"
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      {
        "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Vocat Sch Hlth Serv, Istanbul, Turkey", 
        "name": "Tumentemur, Gamze"
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      {
        "affiliation": "Yeditepe Univ, Genet & Bioengn Dept, Istanbul, Turkey", 
        "name": "Demir, Sevda"
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      {
        "name": "Turan, Raife Dilek"
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      {
        "name": "Abanuz, Selen"
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        "name": "Cakirsoy, Didem"
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      {
        "affiliation": "Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey", 
        "name": "Seyis, Utku"
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      {
        "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Anim Applicat & Res Ctr, Istanbul, Turkey", 
        "name": "Ozer, Samed"
      }, 
      {
        "affiliation": "Acibadem Altunizade Hosp, Istanbul, Turkey", 
        "name": "Elibol, Omer"
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      {
        "name": "Elek, Muhammer"
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      {
        "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Vocat Sch Hlth Serv, Istanbul, Turkey", 
        "name": "Ertop, Gurcan"
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      {
        "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Histol & Embryol Dept, Istanbul, Turkey", 
        "name": "Arbale, Serap"
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      {
        "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Histol & Embryol Dept, Istanbul, Turkey", 
        "name": "Elmas, Merve Acikel"
      }, 
      {
        "affiliation": "Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey", 
        "name": "Hermsinlioglu, Canso"
      }, 
      {
        "affiliation": "Acibadem Altunizade Hosp, Infect Dis Unit, Istanbul, Turkey", 
        "name": "Kocagoz, Ayse Sesin"
      }, 
      {
        "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Med Biol Dept, Istanbul, Turkey", 
        "name": "Ng, Ozden Hatirnaz"
      }, 
      {
        "name": "Akyoney, Sezer"
      }, 
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        "name": "Akyoney, Sezer"
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    ], 
    "description": "COVID-19 outbreak caused by SARS-CoV-2 created an unprecedented health crisis since there is no vaccine for this novel virus. Therefore, SARS-CoV-2 vaccines have become crucial for reducing morbidity and mortality. In this study, in vitro and in vivo safety and efficacy analyzes of lyophilized vaccine candidates inactivated by gamma-irradiation were performed. The candidate vaccines in this study were OZG-3861 version 1(V1), an inactivated SARS-CoV-2 virus vaccine, and SK-01 version 1 (V1), a GM-CSF adjuvant added vaccine. The candidate vaccines were applied intradermally to BALB/c mice to assess toxicity and immunogenicity. Preliminary results in vaccinated mice are reported in this study. Especially, the vaccine models containing GM-CSF caused significant antibody production with neutralization capacity in absence of the antibody-dependent enhancement feature, when considered in terms of T and B cell responses. Another important finding was that the presence of adjuvant was more important in T cell in comparison with B cell response. Vaccinated mice showed T cell response upon restimulation with whole inactivated SARS-CoV-2 or peptide pool. This study shows that the vaccines are effective and leads us to start the challenge test to investigate the gamma-irradiated inactivated vaccine candidates for infective SARS-CoV-2 virus in humanized ACE2+ mice.", 
    "doi": "10.1038/s41598-021-83930-6", 
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    "journal": {
      "issue": "1", 
      "title": "SCIENTIFIC REPORTS", 
      "volume": "11"
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    "publication_date": "2021-01-01", 
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      "title": "Dergi makalesi", 
      "type": "publication"
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    "science_branches": [
      "Di\u011fer"
    ], 
    "title": "Preclinical efficacy and safety analysis of gamma-irradiated inactivated SARS-CoV-2 vaccine candidates"
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