1 Ocak 2021 Dergi makalesi Açık Erişim

Karakus, Gozde Sir; Tastan, Cihan; Kancagi, Derya Dilek; Yurtsever, Bulut; Tumentemur, Gamze; Demir, Sevda; Turan, Raife Dilek; Abanuz, Selen; Cakirsoy, Didem; Seyis, Utku; Ozer, Samed; Elibol, Omer; Elek, Muhammer; Ertop, Gurcan; Arbale, Serap; Elmas, Merve Acikel; Hermsinlioglu, Canso; Kocagoz, Ayse Sesin; Ng, Ozden Hatirnaz; Akyoney, Sezer; Akyoney, Sezer

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/231896</identifier>
  <creators>
    <creator>
      <creatorName>Karakus, Gozde Sir</creatorName>
      <givenName>Gozde Sir</givenName>
      <familyName>Karakus</familyName>
      <affiliation>Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tastan, Cihan</creatorName>
      <givenName>Cihan</givenName>
      <familyName>Tastan</familyName>
    </creator>
    <creator>
      <creatorName>Kancagi, Derya Dilek</creatorName>
      <givenName>Derya Dilek</givenName>
      <familyName>Kancagi</familyName>
      <affiliation>Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yurtsever, Bulut</creatorName>
      <givenName>Bulut</givenName>
      <familyName>Yurtsever</familyName>
      <affiliation>Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tumentemur, Gamze</creatorName>
      <givenName>Gamze</givenName>
      <familyName>Tumentemur</familyName>
      <affiliation>Acibadem Mehmet Ali Aydinlar Univ, Vocat Sch Hlth Serv, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Demir, Sevda</creatorName>
      <givenName>Sevda</givenName>
      <familyName>Demir</familyName>
      <affiliation>Yeditepe Univ, Genet &amp; Bioengn Dept, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Turan, Raife Dilek</creatorName>
      <givenName>Raife Dilek</givenName>
      <familyName>Turan</familyName>
    </creator>
    <creator>
      <creatorName>Abanuz, Selen</creatorName>
      <givenName>Selen</givenName>
      <familyName>Abanuz</familyName>
    </creator>
    <creator>
      <creatorName>Cakirsoy, Didem</creatorName>
      <givenName>Didem</givenName>
      <familyName>Cakirsoy</familyName>
    </creator>
    <creator>
      <creatorName>Seyis, Utku</creatorName>
      <givenName>Utku</givenName>
      <familyName>Seyis</familyName>
      <affiliation>Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozer, Samed</creatorName>
      <givenName>Samed</givenName>
      <familyName>Ozer</familyName>
      <affiliation>Acibadem Mehmet Ali Aydinlar Univ, Anim Applicat &amp; Res Ctr, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Elibol, Omer</creatorName>
      <givenName>Omer</givenName>
      <familyName>Elibol</familyName>
      <affiliation>Acibadem Altunizade Hosp, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Elek, Muhammer</creatorName>
      <givenName>Muhammer</givenName>
      <familyName>Elek</familyName>
    </creator>
    <creator>
      <creatorName>Ertop, Gurcan</creatorName>
      <givenName>Gurcan</givenName>
      <familyName>Ertop</familyName>
      <affiliation>Acibadem Mehmet Ali Aydinlar Univ, Vocat Sch Hlth Serv, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Arbale, Serap</creatorName>
      <givenName>Serap</givenName>
      <familyName>Arbale</familyName>
      <affiliation>Acibadem Mehmet Ali Aydinlar Univ, Histol &amp; Embryol Dept, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Elmas, Merve Acikel</creatorName>
      <givenName>Merve Acikel</givenName>
      <familyName>Elmas</familyName>
      <affiliation>Acibadem Mehmet Ali Aydinlar Univ, Histol &amp; Embryol Dept, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Hermsinlioglu, Canso</creatorName>
      <givenName>Canso</givenName>
      <familyName>Hermsinlioglu</familyName>
      <affiliation>Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kocagoz, Ayse Sesin</creatorName>
      <givenName>Ayse Sesin</givenName>
      <familyName>Kocagoz</familyName>
      <affiliation>Acibadem Altunizade Hosp, Infect Dis Unit, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ng, Ozden Hatirnaz</creatorName>
      <givenName>Ozden Hatirnaz</givenName>
      <familyName>Ng</familyName>
      <affiliation>Acibadem Mehmet Ali Aydinlar Univ, Med Biol Dept, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akyoney, Sezer</creatorName>
      <givenName>Sezer</givenName>
      <familyName>Akyoney</familyName>
    </creator>
    <creator>
      <creatorName>Akyoney, Sezer</creatorName>
      <givenName>Sezer</givenName>
      <familyName>Akyoney</familyName>
    </creator>
  </creators>
  <titles>
    <title>Preclinical Efficacy And Safety Analysis Of Gamma-Irradiated Inactivated Sars-Cov-2 Vaccine Candidates</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/231896</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1038/s41598-021-83930-6</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">COVID-19 outbreak caused by SARS-CoV-2 created an unprecedented health crisis since there is no vaccine for this novel virus. Therefore, SARS-CoV-2 vaccines have become crucial for reducing morbidity and mortality. In this study, in vitro and in vivo safety and efficacy analyzes of lyophilized vaccine candidates inactivated by gamma-irradiation were performed. The candidate vaccines in this study were OZG-3861 version 1(V1), an inactivated SARS-CoV-2 virus vaccine, and SK-01 version 1 (V1), a GM-CSF adjuvant added vaccine. The candidate vaccines were applied intradermally to BALB/c mice to assess toxicity and immunogenicity. Preliminary results in vaccinated mice are reported in this study. Especially, the vaccine models containing GM-CSF caused significant antibody production with neutralization capacity in absence of the antibody-dependent enhancement feature, when considered in terms of T and B cell responses. Another important finding was that the presence of adjuvant was more important in T cell in comparison with B cell response. Vaccinated mice showed T cell response upon restimulation with whole inactivated SARS-CoV-2 or peptide pool. This study shows that the vaccines are effective and leads us to start the challenge test to investigate the gamma-irradiated inactivated vaccine candidates for infective SARS-CoV-2 virus in humanized ACE2+ mice.</description>
  </descriptions>
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