Dergi makalesi Açık Erişim

Effects of sitagliptin on beta-adrenoceptor mediated relaxation in streptozotocin-diabetic rat aorta

Muderrisoglu, Ayhanim Elif; Erdogan, Betul Rabia; Yesilyurt, Zeynep Elif; Boztas, Ceren Uyar; Karacomerlioglu, Irem; Altan, Vecdi Melih; Inan, Ebru Arioglu


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      {
        "affiliation": "Ankara Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey", 
        "name": "Muderrisoglu, Ayhanim Elif"
      }, 
      {
        "affiliation": "Ankara Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey", 
        "name": "Erdogan, Betul Rabia"
      }, 
      {
        "affiliation": "Ankara Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey", 
        "name": "Yesilyurt, Zeynep Elif"
      }, 
      {
        "affiliation": "Ankara Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey", 
        "name": "Boztas, Ceren Uyar"
      }, 
      {
        "affiliation": "Ankara Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey", 
        "name": "Karacomerlioglu, Irem"
      }, 
      {
        "affiliation": "Bezmialem Vakif Univ, Fac Pharm, Dept Pharmacol, Istanbul, Turkey", 
        "name": "Altan, Vecdi Melih"
      }, 
      {
        "affiliation": "Ankara Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey", 
        "name": "Inan, Ebru Arioglu"
      }
    ], 
    "description": "Background/aim: Dipeptidyl peptidase-4 (DPP4) inhibitors, a class of oral antidiabetic drugs, have been shown to be protective on the vascular system because of their antiinflammatory, antiatherosclerotic, and vasodilatory effects. beta(2)-adrenoceptors (beta(2)-ARs) mediate the vasorelaxation in the aorta. However, beta(3)-adrenoceptor-mediated relaxation has not been studied in diabetic aorta yet. Thus, we aimed to study the effect of sitagliptin treatment on beta(2)- and beta(3)-adrenoceptor-mediated relaxations in the diabetic rat aorta.", 
    "doi": "10.3906/sag-2007-234", 
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    "journal": {
      "issue": "2", 
      "pages": "864-872", 
      "title": "TURKISH JOURNAL OF MEDICAL SCIENCES", 
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    "title": "Effects of sitagliptin on beta-adrenoceptor mediated relaxation in streptozotocin-diabetic rat aorta"
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