Dergi makalesi Açık Erişim

Effects of sitagliptin on beta-adrenoceptor mediated relaxation in streptozotocin-diabetic rat aorta

2021    Muderrisoglu, Ayhanim Elif; Erdogan, Betul Rabia; Yesilyurt, Zeynep Elif; Boztas, Ceren Uyar; Karacomerlioglu, Irem; Altan, Vecdi Melih; Inan, Ebru Arioglu

Background/aim: Dipeptidyl peptidase-4 (DPP4) inhibitors, a class of oral antidiabetic drugs, have been shown to be protective on the vascular system because of their antiinflammatory, antiatherosclerotic, and vasodilatory effects. beta(2)-adrenoceptors (beta(2)-ARs) mediate the vasorelaxation in the aorta. However, beta(3)-adrenoceptor-mediated relaxation has not been studied in diabetic aorta yet. Thus, we aimed to study the effect of sitagliptin treatment on beta(2)- and beta(3)-adrenoceptor-mediated relaxations in the diabetic rat aorta.