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Effects of sitagliptin on beta-adrenoceptor mediated relaxation in streptozotocin-diabetic rat aorta

Muderrisoglu, Ayhanim Elif; Erdogan, Betul Rabia; Yesilyurt, Zeynep Elif; Boztas, Ceren Uyar; Karacomerlioglu, Irem; Altan, Vecdi Melih; Inan, Ebru Arioglu


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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/230430</identifier>
  <creators>
    <creator>
      <creatorName>Muderrisoglu, Ayhanim Elif</creatorName>
      <givenName>Ayhanim Elif</givenName>
      <familyName>Muderrisoglu</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Erdogan, Betul Rabia</creatorName>
      <givenName>Betul Rabia</givenName>
      <familyName>Erdogan</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yesilyurt, Zeynep Elif</creatorName>
      <givenName>Zeynep Elif</givenName>
      <familyName>Yesilyurt</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Boztas, Ceren Uyar</creatorName>
      <givenName>Ceren Uyar</givenName>
      <familyName>Boztas</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Karacomerlioglu, Irem</creatorName>
      <givenName>Irem</givenName>
      <familyName>Karacomerlioglu</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Altan, Vecdi Melih</creatorName>
      <givenName>Vecdi Melih</givenName>
      <familyName>Altan</familyName>
      <affiliation>Bezmialem Vakif Univ, Fac Pharm, Dept Pharmacol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Inan, Ebru Arioglu</creatorName>
      <givenName>Ebru Arioglu</givenName>
      <familyName>Inan</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Effects Of Sitagliptin On Beta-Adrenoceptor Mediated Relaxation In Streptozotocin-Diabetic Rat Aorta</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/230430</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.3906/sag-2007-234</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Background/aim: Dipeptidyl peptidase-4 (DPP4) inhibitors, a class of oral antidiabetic drugs, have been shown to be protective on the vascular system because of their antiinflammatory, antiatherosclerotic, and vasodilatory effects. beta(2)-adrenoceptors (beta(2)-ARs) mediate the vasorelaxation in the aorta. However, beta(3)-adrenoceptor-mediated relaxation has not been studied in diabetic aorta yet. Thus, we aimed to study the effect of sitagliptin treatment on beta(2)- and beta(3)-adrenoceptor-mediated relaxations in the diabetic rat aorta.</description>
  </descriptions>
</resource>
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