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Effects of sitagliptin on beta-adrenoceptor mediated relaxation in streptozotocin-diabetic rat aorta

Muderrisoglu, Ayhanim Elif; Erdogan, Betul Rabia; Yesilyurt, Zeynep Elif; Boztas, Ceren Uyar; Karacomerlioglu, Irem; Altan, Vecdi Melih; Inan, Ebru Arioglu


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{
  "DOI": "10.3906/sag-2007-234", 
  "abstract": "Background/aim: Dipeptidyl peptidase-4 (DPP4) inhibitors, a class of oral antidiabetic drugs, have been shown to be protective on the vascular system because of their antiinflammatory, antiatherosclerotic, and vasodilatory effects. beta(2)-adrenoceptors (beta(2)-ARs) mediate the vasorelaxation in the aorta. However, beta(3)-adrenoceptor-mediated relaxation has not been studied in diabetic aorta yet. Thus, we aimed to study the effect of sitagliptin treatment on beta(2)- and beta(3)-adrenoceptor-mediated relaxations in the diabetic rat aorta.", 
  "author": [
    {
      "family": "Muderrisoglu", 
      "given": " Ayhanim Elif"
    }, 
    {
      "family": "Erdogan", 
      "given": " Betul Rabia"
    }, 
    {
      "family": "Yesilyurt", 
      "given": " Zeynep Elif"
    }, 
    {
      "family": "Boztas", 
      "given": " Ceren Uyar"
    }, 
    {
      "family": "Karacomerlioglu", 
      "given": " Irem"
    }, 
    {
      "family": "Altan", 
      "given": " Vecdi Melih"
    }, 
    {
      "family": "Inan", 
      "given": " Ebru Arioglu"
    }
  ], 
  "container_title": "TURKISH JOURNAL OF MEDICAL SCIENCES", 
  "id": "230430", 
  "issue": "2", 
  "issued": {
    "date-parts": [
      [
        2021, 
        1, 
        1
      ]
    ]
  }, 
  "page": "864-872", 
  "title": "Effects of sitagliptin on beta-adrenoceptor mediated relaxation in streptozotocin-diabetic rat aorta", 
  "type": "article-journal", 
  "volume": "51"
}
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