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Reactions of acyl phosphonates with organoaluminum reagents: a new method for the synthesis of secondary and tertiary alpha-hydroxy phosphonates

Seven, Ozlem; Polat-Cakir, Sidika; Hossain, Md. Shakhawoat; Emrullahoglu, Mustafa; Demir, Ayhan S.


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        "affiliation": "Middle E Tech Univ, Dept Chem, TR-06531 Ankara, Turkey", 
        "name": "Seven, Ozlem"
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      {
        "name": "Polat-Cakir, Sidika"
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      {
        "affiliation": "Middle E Tech Univ, Dept Chem, TR-06531 Ankara, Turkey", 
        "name": "Hossain, Md. Shakhawoat"
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      {
        "name": "Emrullahoglu, Mustafa"
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        "affiliation": "Middle E Tech Univ, Dept Chem, TR-06531 Ankara, Turkey", 
        "name": "Demir, Ayhan S."
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    "description": "The reactions of organoaluminum reagents (trimethylaluminum, triethylaluminum, etc.) with aryl and alkyl acyl phosphonates, which lead to the formation of alpha-hydroxy phosphonates in moderate to good yields, are reported. This method provides easy access to secondary and tertiary alpha-hydroxy phosphonates depending on the reaction conditions. The reactions of triethylaluminum with a series of acyl phosphonates at 0 degrees C gave the secondary alpha-hydroxy phosphonates, while at -100 degrees C they afford the tertiary alpha-hydroxy phosphonates. (C) 2011 Elsevier Ltd. All rights reserved.", 
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      "issue": "19", 
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