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Reactions of acyl phosphonates with organoaluminum reagents: a new method for the synthesis of secondary and tertiary alpha-hydroxy phosphonates

Seven, Ozlem; Polat-Cakir, Sidika; Hossain, Md. Shakhawoat; Emrullahoglu, Mustafa; Demir, Ayhan S.


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{
  "DOI": "10.1016/j.tet.2011.03.036", 
  "abstract": "The reactions of organoaluminum reagents (trimethylaluminum, triethylaluminum, etc.) with aryl and alkyl acyl phosphonates, which lead to the formation of alpha-hydroxy phosphonates in moderate to good yields, are reported. This method provides easy access to secondary and tertiary alpha-hydroxy phosphonates depending on the reaction conditions. The reactions of triethylaluminum with a series of acyl phosphonates at 0 degrees C gave the secondary alpha-hydroxy phosphonates, while at -100 degrees C they afford the tertiary alpha-hydroxy phosphonates. (C) 2011 Elsevier Ltd. All rights reserved.", 
  "author": [
    {
      "family": "Seven", 
      "given": " Ozlem"
    }, 
    {
      "family": "Polat-Cakir", 
      "given": " Sidika"
    }, 
    {
      "family": "Hossain", 
      "given": " Md. Shakhawoat"
    }, 
    {
      "family": "Emrullahoglu", 
      "given": " Mustafa"
    }, 
    {
      "family": "Demir", 
      "given": " Ayhan S."
    }
  ], 
  "container_title": "TETRAHEDRON", 
  "id": "22931", 
  "issue": "19", 
  "issued": {
    "date-parts": [
      [
        2011, 
        1, 
        1
      ]
    ]
  }, 
  "page": "3464-3469", 
  "title": "Reactions of acyl phosphonates with organoaluminum reagents: a new method for the synthesis of secondary and tertiary alpha-hydroxy phosphonates", 
  "type": "article-journal", 
  "volume": "67"
}
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