30 Ağustos 2021 Dergi makalesi Açık Erişim

Busra; Belma

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{
  "@context": "https://schema.org/", 
  "@id": 227985, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@id": "https://orcid.org/0000-0001-9863-683X", 
      "@type": "Person", 
      "affiliation": "AKTAS", 
      "name": "Busra"
    }, 
    {
      "@id": "https://orcid.org/0000-0002-0595-7237", 
      "@type": "Person", 
      "affiliation": "ASLIM", 
      "name": "Belma"
    }
  ], 
  "datePublished": "2021-08-30", 
  "description": "<p>Although COVID-19 affects mainly lungs with a hyperactive and imbalanced immune response, gastrointestinal and&nbsp;neurological symptoms such as diarrhea and neuropathic pains have been described as well in patients with COVID-19. Studies indicate&nbsp;that gut&ndash;lung axis maintains host homeostasis and disease development with the association of immune system, and gut microbiota is&nbsp;involved in the COVID-19 severity in patients with extrapulmonary conditions. Gut microbiota dysbiosis impairs the gut permeability&nbsp;resulting in translocation of gut microbes and their metabolites into the circulatory system and induce systemic inflammation which,&nbsp;in turn, can affect distal organs such as the brain. Moreover, gut microbiota maintains the availability of tryptophan for kynurenine&nbsp;pathway, which is important for both central nervous and gastrointestinal system in regulating inflammation. SARS-CoV-2 infection&nbsp;disturbs the gut microbiota and leads to immune dysfunction with generalized inflammation. It has been known that cytokines&nbsp;and microbial products crossing the blood-brain barrier induce the neuroinflammation, which contributes to the pathophysiology&nbsp;of neurodegenerative diseases including neuropathies. Therefore, we believe that both gut&ndash;lung and gut&ndash;brain axes are involved in&nbsp;COVID-19 severity and extrapulmonary complications. Furthermore, gut microbial dysbiosis could be the reason of the neurologic&nbsp;complications seen in severe COVID-19 patients with the association of dysbiosis-related neuroinflammation. This review will provide&nbsp;valuable insights into the role of gut microbiota dysbiosis and dysbiosis-related inflammation on the neuropathy in COVID-19 patients&nbsp;and the disease severity.</p>", 
  "headline": "Neuropathy in COVID-19 associated with dysbiosis-related inflammation", 
  "identifier": 227985, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "keywords": [
    "COVID-19", 
    "gut microbiota dysbiosis", 
    "neuropathy", 
    "inflammation", 
    "gut\u2013lung axis", 
    "gut\u2013brain axis"
  ], 
  "license": "http://www.opendefinition.org/licenses/cc-by-sa", 
  "name": "Neuropathy in COVID-19 associated with dysbiosis-related inflammation", 
  "url": "https://aperta.ulakbim.gov.tr/record/227985"
}