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<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="540" ind1=" " ind2=" "> <subfield code="u">http://www.opendefinition.org/licenses/cc-by-sa</subfield> <subfield code="a">Creative Commons Attribution Share-Alike</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">COVID-19</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">gut microbiota dysbiosis</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">neuropathy</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">inflammation</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">gut–lung axis</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">gut–brain axis</subfield> </datafield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:zenodo.org:227985</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a"><p>Although COVID-19 affects mainly lungs with a hyperactive and imbalanced immune response, gastrointestinal and&nbsp;neurological symptoms such as diarrhea and neuropathic pains have been described as well in patients with COVID-19. Studies indicate&nbsp;that gut&ndash;lung axis maintains host homeostasis and disease development with the association of immune system, and gut microbiota is&nbsp;involved in the COVID-19 severity in patients with extrapulmonary conditions. Gut microbiota dysbiosis impairs the gut permeability&nbsp;resulting in translocation of gut microbes and their metabolites into the circulatory system and induce systemic inflammation which,&nbsp;in turn, can affect distal organs such as the brain. Moreover, gut microbiota maintains the availability of tryptophan for kynurenine&nbsp;pathway, which is important for both central nervous and gastrointestinal system in regulating inflammation. SARS-CoV-2 infection&nbsp;disturbs the gut microbiota and leads to immune dysfunction with generalized inflammation. It has been known that cytokines&nbsp;and microbial products crossing the blood-brain barrier induce the neuroinflammation, which contributes to the pathophysiology&nbsp;of neurodegenerative diseases including neuropathies. Therefore, we believe that both gut&ndash;lung and gut&ndash;brain axes are involved in&nbsp;COVID-19 severity and extrapulmonary complications. Furthermore, gut microbial dysbiosis could be the reason of the neurologic&nbsp;complications seen in severe COVID-19 patients with the association of dysbiosis-related neuroinflammation. This review will provide&nbsp;valuable insights into the role of gut microbiota dysbiosis and dysbiosis-related inflammation on the neuropathy in COVID-19 patients&nbsp;and the disease severity.</p></subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="a">cc-by</subfield> <subfield code="2">opendefinition.org</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="n">SI-1</subfield> <subfield code="v">45</subfield> <subfield code="c">390-403</subfield> <subfield code="p">Turkish Journal of Biology</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2021-08-30</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.3906/biy-2105-53</subfield> <subfield code="2">doi</subfield> </datafield> <controlfield tag="001">227985</controlfield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="a">Busra</subfield> <subfield code="0">(orcid)0000-0001-9863-683X</subfield> <subfield code="u">AKTAS</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="u">https://aperta.ulakbim.gov.trrecord/227985/files/biy-45-si-1-4-2105-53.pdf</subfield> <subfield code="s">157497</subfield> <subfield code="z">md5:85ee469551f24c044449f82f278643bb</subfield> </datafield> <controlfield tag="005">20210913070759.0</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">publication</subfield> <subfield code="b">article</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Belma</subfield> <subfield code="0">(orcid)0000-0002-0595-7237</subfield> <subfield code="u">ASLIM</subfield> </datafield> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Neuropathy in COVID-19 associated with dysbiosis-related inflammation</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> </record>
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