30 Ağustos 2021 Dergi makalesi Açık Erişim

Busra; Belma

JSON

{
  "conceptrecid": "227984", 
  "created": "2021-09-13T07:07:59.708876+00:00", 
  "doi": "10.3906/biy-2105-53", 
  "files": [
    {
      "bucket": "419a37e0-7eda-420f-8b72-fa9e48a0bd28", 
      "checksum": "md5:85ee469551f24c044449f82f278643bb", 
      "key": "biy-45-si-1-4-2105-53.pdf", 
      "links": {
        "self": "https://aperta.ulakbim.gov.tr/api/files/419a37e0-7eda-420f-8b72-fa9e48a0bd28/biy-45-si-1-4-2105-53.pdf"
      }, 
      "size": 157497, 
      "type": "pdf"
    }
  ], 
  "id": 227985, 
  "links": {
    "badge": "https://aperta.ulakbim.gov.tr/badge/doi/10.3906/biy-2105-53.svg", 
    "bucket": "https://aperta.ulakbim.gov.tr/api/files/419a37e0-7eda-420f-8b72-fa9e48a0bd28", 
    "doi": "https://doi.org/10.3906/biy-2105-53", 
    "html": "https://aperta.ulakbim.gov.tr/record/227985", 
    "latest": "https://aperta.ulakbim.gov.tr/api/records/227985", 
    "latest_html": "https://aperta.ulakbim.gov.tr/record/227985"
  }, 
  "metadata": {
    "access_right": "open", 
    "access_right_category": "success", 
    "creators": [
      {
        "affiliation": "AKTAS", 
        "name": "Busra", 
        "orcid": "0000-0001-9863-683X"
      }, 
      {
        "affiliation": "ASLIM", 
        "name": "Belma", 
        "orcid": "0000-0002-0595-7237"
      }
    ], 
    "description": "<p>Although COVID-19 affects mainly lungs with a hyperactive and imbalanced immune response, gastrointestinal and&nbsp;neurological symptoms such as diarrhea and neuropathic pains have been described as well in patients with COVID-19. Studies indicate&nbsp;that gut&ndash;lung axis maintains host homeostasis and disease development with the association of immune system, and gut microbiota is&nbsp;involved in the COVID-19 severity in patients with extrapulmonary conditions. Gut microbiota dysbiosis impairs the gut permeability&nbsp;resulting in translocation of gut microbes and their metabolites into the circulatory system and induce systemic inflammation which,&nbsp;in turn, can affect distal organs such as the brain. Moreover, gut microbiota maintains the availability of tryptophan for kynurenine&nbsp;pathway, which is important for both central nervous and gastrointestinal system in regulating inflammation. SARS-CoV-2 infection&nbsp;disturbs the gut microbiota and leads to immune dysfunction with generalized inflammation. It has been known that cytokines&nbsp;and microbial products crossing the blood-brain barrier induce the neuroinflammation, which contributes to the pathophysiology&nbsp;of neurodegenerative diseases including neuropathies. Therefore, we believe that both gut&ndash;lung and gut&ndash;brain axes are involved in&nbsp;COVID-19 severity and extrapulmonary complications. Furthermore, gut microbial dysbiosis could be the reason of the neurologic&nbsp;complications seen in severe COVID-19 patients with the association of dysbiosis-related neuroinflammation. This review will provide&nbsp;valuable insights into the role of gut microbiota dysbiosis and dysbiosis-related inflammation on the neuropathy in COVID-19 patients&nbsp;and the disease severity.</p>", 
    "doi": "10.3906/biy-2105-53", 
    "has_grant": false, 
    "journal": {
      "issue": "SI-1", 
      "pages": "390-403", 
      "title": "Turkish Journal of Biology", 
      "volume": "45"
    }, 
    "keywords": [
      "COVID-19", 
      "gut microbiota dysbiosis", 
      "neuropathy", 
      "inflammation", 
      "gut\u2013lung axis", 
      "gut\u2013brain axis"
    ], 
    "license": {
      "id": "cc-by-sa"
    }, 
    "publication_date": "2021-08-30", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "227985"
          }, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "227984"
          }
        }
      ]
    }, 
    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "science_branches": [
      "Temel Bilimler > Ya\u015fam Bilimleri > Molek\u00fcler Biyoloji ve Genetik"
    ], 
    "title": "Neuropathy in COVID-19 associated with dysbiosis-related inflammation"
  }, 
  "owners": [
    34
  ], 
  "revision": 1, 
  "stats": {
    "downloads": 78.0, 
    "unique_downloads": 74.0, 
    "unique_views": 212.0, 
    "version_downloads": 78.0, 
    "version_unique_downloads": 74.0, 
    "version_unique_views": 212.0, 
    "version_views": 254.0, 
    "version_volume": 12284766.0, 
    "views": 254.0, 
    "volume": 12284766.0
  }, 
  "updated": "2021-09-13T07:07:59.763937+00:00"
}