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Neuropathy in COVID-19 associated with dysbiosis-related inflammation

Busra; Belma


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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr//record/227985</identifier>
  <creators>
    <creator>
      <creatorName>Busra</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0001-9863-683X</nameIdentifier>
      <affiliation>AKTAS</affiliation>
    </creator>
    <creator>
      <creatorName>Belma</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-0595-7237</nameIdentifier>
      <affiliation>ASLIM</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Neuropathy In Covid-19 Associated With Dysbiosis-Related Inflammation</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <subjects>
    <subject>COVID-19</subject>
    <subject>gut microbiota dysbiosis</subject>
    <subject>neuropathy</subject>
    <subject>inflammation</subject>
    <subject>gut–lung axis</subject>
    <subject>gut–brain axis</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2021-08-30</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr//record/227985</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.3906/biy-2105-53</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by-sa">Creative Commons Attribution Share-Alike</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;Although COVID-19 affects mainly lungs with a hyperactive and imbalanced immune response, gastrointestinal and&amp;nbsp;neurological symptoms such as diarrhea and neuropathic pains have been described as well in patients with COVID-19. Studies indicate&amp;nbsp;that gut&amp;ndash;lung axis maintains host homeostasis and disease development with the association of immune system, and gut microbiota is&amp;nbsp;involved in the COVID-19 severity in patients with extrapulmonary conditions. Gut microbiota dysbiosis impairs the gut permeability&amp;nbsp;resulting in translocation of gut microbes and their metabolites into the circulatory system and induce systemic inflammation which,&amp;nbsp;in turn, can affect distal organs such as the brain. Moreover, gut microbiota maintains the availability of tryptophan for kynurenine&amp;nbsp;pathway, which is important for both central nervous and gastrointestinal system in regulating inflammation. SARS-CoV-2 infection&amp;nbsp;disturbs the gut microbiota and leads to immune dysfunction with generalized inflammation. It has been known that cytokines&amp;nbsp;and microbial products crossing the blood-brain barrier induce the neuroinflammation, which contributes to the pathophysiology&amp;nbsp;of neurodegenerative diseases including neuropathies. Therefore, we believe that both gut&amp;ndash;lung and gut&amp;ndash;brain axes are involved in&amp;nbsp;COVID-19 severity and extrapulmonary complications. Furthermore, gut microbial dysbiosis could be the reason of the neurologic&amp;nbsp;complications seen in severe COVID-19 patients with the association of dysbiosis-related neuroinflammation. This review will provide&amp;nbsp;valuable insights into the role of gut microbiota dysbiosis and dysbiosis-related inflammation on the neuropathy in COVID-19 patients&amp;nbsp;and the disease severity.&lt;/p&gt;</description>
  </descriptions>
</resource>
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