30 Ağustos 2021 Dergi makalesi Açık Erişim

Mehmet; Gökhan; Pamir

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Pathogenesis and treatment of cytokine storm in COVID-19</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="p">Turkish Journal of Biology</subfield>
    <subfield code="v">45</subfield>
    <subfield code="n">SI-1</subfield>
    <subfield code="c">372-389</subfield>
  </datafield>
  <controlfield tag="001">227983</controlfield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">&lt;p&gt;COVID-19 is a viral infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that killed a large&amp;nbsp;number of patients around the world. A hyperinflammatory state resulting in a cytokine storm and adult respiratory distress syndrome&amp;nbsp;seems to be the major cause of the death. Many mechanisms have been suggested in the pathogenesis of COVID-19 associated cytokine&amp;nbsp;storm (COVID-CS). Insufficient viral clearance and persistence of a strong cytokine response despite inadequate antiviral immunity&amp;nbsp;seem to be the main mechanisms underlying the pathogenesis. The diagnosis of COVID-19 is based on relatively constant clinical&amp;nbsp;symptoms, clinical findings, laboratory tests, and imaging techniques, while the diagnosis of COVID-CS is a rather dynamic process,&amp;nbsp;based on evolving or newly emerging findings during the clinical course. Management of COVID-19 consists of using antiviral agents&amp;nbsp;to inhibit SARS-CoV-2 replication and treating potential complications including the cytokine storm together with general supportive&amp;nbsp;measures. COVID-CS may be treated using appropriate immunosuppressive and immunomodulatory drugs that reduce the level of&amp;nbsp;inappropriate systemic inflammation, which has the potential to cause organ damage. Currently corticosteroids, IL-6 blockers, or IL-1&amp;nbsp;blockers are most widely used for treating COVID-CS.&lt;/p&gt;</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="2">opendefinition.org</subfield>
    <subfield code="a">cc-by</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="0">(orcid)0000-0001-7289-1816</subfield>
    <subfield code="u">KESER</subfield>
    <subfield code="a">Gökhan</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="0">(orcid)0000-0002-6393-7461</subfield>
    <subfield code="u">ATAGÜNDÜZ</subfield>
    <subfield code="a">Pamir</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="b">article</subfield>
    <subfield code="a">publication</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="0">(orcid)0000-0003-1710-7018</subfield>
    <subfield code="u">SOY</subfield>
    <subfield code="a">Mehmet</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">COVID-19</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">SARS-CoV-2</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">cytokine storm</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">acute respiratory distress syndrome</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">tocilizumab</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">anakinra</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2021-08-30</subfield>
  </datafield>
  <controlfield tag="005">20210913070432.0</controlfield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="o">oai:zenodo.org:227983</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="z">md5:f659dedf9b8598ed0300523860109239</subfield>
    <subfield code="s">715886</subfield>
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/227983/files/biy-45-si-1-3-2105-37.pdf</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by-sa</subfield>
    <subfield code="a">Creative Commons Attribution Share-Alike</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.3906/biy-2105-37</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
</record>