Dergi makalesi Açık Erişim

Pathogenesis and treatment of cytokine storm in COVID-19

Mehmet; Gökhan; Pamir


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        "affiliation": "SOY", 
        "name": "Mehmet", 
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        "affiliation": "KESER", 
        "name": "G\u00f6khan", 
        "orcid": "0000-0001-7289-1816"
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      {
        "affiliation": "ATAG\u00dcND\u00dcZ", 
        "name": "Pamir", 
        "orcid": "0000-0002-6393-7461"
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    "description": "<p>COVID-19 is a viral infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that killed a large&nbsp;number of patients around the world. A hyperinflammatory state resulting in a cytokine storm and adult respiratory distress syndrome&nbsp;seems to be the major cause of the death. Many mechanisms have been suggested in the pathogenesis of COVID-19 associated cytokine&nbsp;storm (COVID-CS). Insufficient viral clearance and persistence of a strong cytokine response despite inadequate antiviral immunity&nbsp;seem to be the main mechanisms underlying the pathogenesis. The diagnosis of COVID-19 is based on relatively constant clinical&nbsp;symptoms, clinical findings, laboratory tests, and imaging techniques, while the diagnosis of COVID-CS is a rather dynamic process,&nbsp;based on evolving or newly emerging findings during the clinical course. Management of COVID-19 consists of using antiviral agents&nbsp;to inhibit SARS-CoV-2 replication and treating potential complications including the cytokine storm together with general supportive&nbsp;measures. COVID-CS may be treated using appropriate immunosuppressive and immunomodulatory drugs that reduce the level of&nbsp;inappropriate systemic inflammation, which has the potential to cause organ damage. Currently corticosteroids, IL-6 blockers, or IL-1&nbsp;blockers are most widely used for treating COVID-CS.</p>", 
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      "issue": "SI-1", 
      "pages": "372-389", 
      "title": "Turkish Journal of Biology", 
      "volume": "45"
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    "keywords": [
      "COVID-19", 
      "SARS-CoV-2", 
      "cytokine storm", 
      "acute respiratory distress syndrome", 
      "tocilizumab", 
      "anakinra"
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    "title": "Pathogenesis and treatment of cytokine storm in COVID-19"
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