1 Ocak 2011 Dergi makalesi Açık Erişim

Komurcu-Bayrak, Evrim; Onat, Altan; Yuzbasiogullari, Berna; Mononen, Nina; Laaksonen, Reijo; Kahonen, Mika; Hergenc, Gulay; Lehtimaki, Terho; Erginel-Unaltuna, Nihan

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  <dc:creator>Komurcu-Bayrak, Evrim</dc:creator>
  <dc:creator>Onat, Altan</dc:creator>
  <dc:creator>Yuzbasiogullari, Berna</dc:creator>
  <dc:creator>Mononen, Nina</dc:creator>
  <dc:creator>Laaksonen, Reijo</dc:creator>
  <dc:creator>Kahonen, Mika</dc:creator>
  <dc:creator>Hergenc, Gulay</dc:creator>
  <dc:creator>Lehtimaki, Terho</dc:creator>
  <dc:creator>Erginel-Unaltuna, Nihan</dc:creator>
  <dc:date>2011-01-01</dc:date>
  <dc:description>The -219G/T (rs405509) and +113G/C (rs440446) polymorphisms within the regulatory region of the apolipoprotein E (APOE) gene have been related to the transcriptional activity of the gene. We examined the effect of the stated polymorphisms and their construct haplotypes with the APOE epsilon 2/epsilon 3/epsilon 4 polymorphism on lipid levels and insulin resistance in the Turkish Adult Risk Factor Study. Randomly selected 1774 adults (mean age, 55.0 +/- 11.7 years; 51.2% women) participating in the population-based Turkish Adult Risk Factor Study were cross-sectionally analyzed for the -219G/T, +113G/C, and epsilon 2/epsilon 3/epsilon 4 polymorphisms as well as their haplotypes. Insulin resistance was defined as the 70th percentile in the sample (&gt; 2.51) of the homeostatic model assessment (HOMA). The frequencies of the -219T and +113C alleles were 0.477 and 0.423, respectively; and those of haplotype 1 (GG epsilon 3) and haplotype 2 (TC epsilon 3) were 44.1% and 41.9%, respectively. The -219G/T and +113G/C genotypes (both P &lt; .04) and diplotypes of haplotype 2 (TC epsilon 3) (P &lt; .014) were inversely related to serum fasting insulin and the HOMA index, even after controlling for 8 relevant covariates, but not to serum lipids. Within the APOE3 group, haplotype 2 (TC-/TC+) heterozygotes had an odds ratio of 0.66 (95% confidence interval, 0.42-0.99) for HOMA of insulin resistance after adjusting for 8 covariates. APOE promoter polymorphisms and their diplotypes are independently related with serum fasting insulin levels and HOMA index among Turks. 2011 Elsevier Inc. All rights reserved.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/18539</dc:identifier>
  <dc:identifier>oai:zenodo.org:18539</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>METABOLISM-CLINICAL AND EXPERIMENTAL 60(5) 655-663</dc:source>
  <dc:title>The APOE -219G/T and +113G/C polymorphisms affect insulin resistance among Turks</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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