1 Ocak 2011 Dergi makalesi Açık Erişim

Komurcu-Bayrak, Evrim; Onat, Altan; Yuzbasiogullari, Berna; Mononen, Nina; Laaksonen, Reijo; Kahonen, Mika; Hergenc, Gulay; Lehtimaki, Terho; Erginel-Unaltuna, Nihan

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{
  "DOI": "10.1016/j.metabol.2010.06.016", 
  "abstract": "The -219G/T (rs405509) and +113G/C (rs440446) polymorphisms within the regulatory region of the apolipoprotein E (APOE) gene have been related to the transcriptional activity of the gene. We examined the effect of the stated polymorphisms and their construct haplotypes with the APOE epsilon 2/epsilon 3/epsilon 4 polymorphism on lipid levels and insulin resistance in the Turkish Adult Risk Factor Study. Randomly selected 1774 adults (mean age, 55.0 +/- 11.7 years; 51.2% women) participating in the population-based Turkish Adult Risk Factor Study were cross-sectionally analyzed for the -219G/T, +113G/C, and epsilon 2/epsilon 3/epsilon 4 polymorphisms as well as their haplotypes. Insulin resistance was defined as the 70th percentile in the sample (> 2.51) of the homeostatic model assessment (HOMA). The frequencies of the -219T and +113C alleles were 0.477 and 0.423, respectively; and those of haplotype 1 (GG epsilon 3) and haplotype 2 (TC epsilon 3) were 44.1% and 41.9%, respectively. The -219G/T and +113G/C genotypes (both P < .04) and diplotypes of haplotype 2 (TC epsilon 3) (P < .014) were inversely related to serum fasting insulin and the HOMA index, even after controlling for 8 relevant covariates, but not to serum lipids. Within the APOE3 group, haplotype 2 (TC-/TC+) heterozygotes had an odds ratio of 0.66 (95% confidence interval, 0.42-0.99) for HOMA of insulin resistance after adjusting for 8 covariates. APOE promoter polymorphisms and their diplotypes are independently related with serum fasting insulin levels and HOMA index among Turks. 2011 Elsevier Inc. All rights reserved.", 
  "author": [
    {
      "family": "Komurcu-Bayrak", 
      "given": " Evrim"
    }, 
    {
      "family": "Onat", 
      "given": " Altan"
    }, 
    {
      "family": "Yuzbasiogullari", 
      "given": " Berna"
    }, 
    {
      "family": "Mononen", 
      "given": " Nina"
    }, 
    {
      "family": "Laaksonen", 
      "given": " Reijo"
    }, 
    {
      "family": "Kahonen", 
      "given": " Mika"
    }, 
    {
      "family": "Hergenc", 
      "given": " Gulay"
    }, 
    {
      "family": "Lehtimaki", 
      "given": " Terho"
    }, 
    {
      "family": "Erginel-Unaltuna", 
      "given": " Nihan"
    }
  ], 
  "container_title": "METABOLISM-CLINICAL AND EXPERIMENTAL", 
  "id": "18539", 
  "issue": "5", 
  "issued": {
    "date-parts": [
      [
        2011, 
        1, 
        1
      ]
    ]
  }, 
  "page": "655-663", 
  "title": "The APOE -219G/T and +113G/C polymorphisms affect insulin resistance among Turks", 
  "type": "article-journal", 
  "volume": "60"
}