1 Ocak 2011 Dergi makalesi Açık Erişim

Komurcu-Bayrak, Evrim; Onat, Altan; Yuzbasiogullari, Berna; Mononen, Nina; Laaksonen, Reijo; Kahonen, Mika; Hergenc, Gulay; Lehtimaki, Terho; Erginel-Unaltuna, Nihan

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/18539</identifier>
  <creators>
    <creator>
      <creatorName>Komurcu-Bayrak, Evrim</creatorName>
      <givenName>Evrim</givenName>
      <familyName>Komurcu-Bayrak</familyName>
      <affiliation>Istanbul Univ, Inst Expt Med, Dept Genet, TR-34080 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Onat, Altan</creatorName>
      <givenName>Altan</givenName>
      <familyName>Onat</familyName>
      <affiliation>Istanbul Univ, Cerrahpasa Med Fac, Dept Cardiol, TR-34099 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yuzbasiogullari, Berna</creatorName>
      <givenName>Berna</givenName>
      <familyName>Yuzbasiogullari</familyName>
    </creator>
    <creator>
      <creatorName>Mononen, Nina</creatorName>
      <givenName>Nina</givenName>
      <familyName>Mononen</familyName>
    </creator>
    <creator>
      <creatorName>Laaksonen, Reijo</creatorName>
      <givenName>Reijo</givenName>
      <familyName>Laaksonen</familyName>
    </creator>
    <creator>
      <creatorName>Kahonen, Mika</creatorName>
      <givenName>Mika</givenName>
      <familyName>Kahonen</familyName>
    </creator>
    <creator>
      <creatorName>Hergenc, Gulay</creatorName>
      <givenName>Gulay</givenName>
      <familyName>Hergenc</familyName>
      <affiliation>Yildiz Tech Univ, Dept Biol, TR-34349 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Lehtimaki, Terho</creatorName>
      <givenName>Terho</givenName>
      <familyName>Lehtimaki</familyName>
    </creator>
    <creator>
      <creatorName>Erginel-Unaltuna, Nihan</creatorName>
      <givenName>Nihan</givenName>
      <familyName>Erginel-Unaltuna</familyName>
      <affiliation>Istanbul Univ, Inst Expt Med, Dept Genet, TR-34080 Istanbul, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>The Apoe -219G/T And +113G/C Polymorphisms Affect Insulin Resistance Among Turks</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2011</publicationYear>
  <dates>
    <date dateType="Issued">2011-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/18539</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.metabol.2010.06.016</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The -219G/T (rs405509) and +113G/C (rs440446) polymorphisms within the regulatory region of the apolipoprotein E (APOE) gene have been related to the transcriptional activity of the gene. We examined the effect of the stated polymorphisms and their construct haplotypes with the APOE epsilon 2/epsilon 3/epsilon 4 polymorphism on lipid levels and insulin resistance in the Turkish Adult Risk Factor Study. Randomly selected 1774 adults (mean age, 55.0 +/- 11.7 years; 51.2% women) participating in the population-based Turkish Adult Risk Factor Study were cross-sectionally analyzed for the -219G/T, +113G/C, and epsilon 2/epsilon 3/epsilon 4 polymorphisms as well as their haplotypes. Insulin resistance was defined as the 70th percentile in the sample (&amp;gt; 2.51) of the homeostatic model assessment (HOMA). The frequencies of the -219T and +113C alleles were 0.477 and 0.423, respectively; and those of haplotype 1 (GG epsilon 3) and haplotype 2 (TC epsilon 3) were 44.1% and 41.9%, respectively. The -219G/T and +113G/C genotypes (both P &amp;lt; .04) and diplotypes of haplotype 2 (TC epsilon 3) (P &amp;lt; .014) were inversely related to serum fasting insulin and the HOMA index, even after controlling for 8 relevant covariates, but not to serum lipids. Within the APOE3 group, haplotype 2 (TC-/TC+) heterozygotes had an odds ratio of 0.66 (95% confidence interval, 0.42-0.99) for HOMA of insulin resistance after adjusting for 8 covariates. APOE promoter polymorphisms and their diplotypes are independently related with serum fasting insulin levels and HOMA index among Turks. 2011 Elsevier Inc. All rights reserved.</description>
  </descriptions>
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