1 Ocak 2011 Dergi makalesi Açık Erişim

Komurcu-Bayrak, Evrim; Onat, Altan; Yuzbasiogullari, Berna; Mononen, Nina; Laaksonen, Reijo; Kahonen, Mika; Hergenc, Gulay; Lehtimaki, Terho; Erginel-Unaltuna, Nihan

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  "@context": "https://schema.org/", 
  "@id": 18539, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Inst Expt Med, Dept Genet, TR-34080 Istanbul, Turkey", 
      "name": "Komurcu-Bayrak, Evrim"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Cerrahpasa Med Fac, Dept Cardiol, TR-34099 Istanbul, Turkey", 
      "name": "Onat, Altan"
    }, 
    {
      "@type": "Person", 
      "name": "Yuzbasiogullari, Berna"
    }, 
    {
      "@type": "Person", 
      "name": "Mononen, Nina"
    }, 
    {
      "@type": "Person", 
      "name": "Laaksonen, Reijo"
    }, 
    {
      "@type": "Person", 
      "name": "Kahonen, Mika"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Yildiz Tech Univ, Dept Biol, TR-34349 Istanbul, Turkey", 
      "name": "Hergenc, Gulay"
    }, 
    {
      "@type": "Person", 
      "name": "Lehtimaki, Terho"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Inst Expt Med, Dept Genet, TR-34080 Istanbul, Turkey", 
      "name": "Erginel-Unaltuna, Nihan"
    }
  ], 
  "datePublished": "2011-01-01", 
  "description": "The -219G/T (rs405509) and +113G/C (rs440446) polymorphisms within the regulatory region of the apolipoprotein E (APOE) gene have been related to the transcriptional activity of the gene. We examined the effect of the stated polymorphisms and their construct haplotypes with the APOE epsilon 2/epsilon 3/epsilon 4 polymorphism on lipid levels and insulin resistance in the Turkish Adult Risk Factor Study. Randomly selected 1774 adults (mean age, 55.0 +/- 11.7 years; 51.2% women) participating in the population-based Turkish Adult Risk Factor Study were cross-sectionally analyzed for the -219G/T, +113G/C, and epsilon 2/epsilon 3/epsilon 4 polymorphisms as well as their haplotypes. Insulin resistance was defined as the 70th percentile in the sample (> 2.51) of the homeostatic model assessment (HOMA). The frequencies of the -219T and +113C alleles were 0.477 and 0.423, respectively; and those of haplotype 1 (GG epsilon 3) and haplotype 2 (TC epsilon 3) were 44.1% and 41.9%, respectively. The -219G/T and +113G/C genotypes (both P < .04) and diplotypes of haplotype 2 (TC epsilon 3) (P < .014) were inversely related to serum fasting insulin and the HOMA index, even after controlling for 8 relevant covariates, but not to serum lipids. Within the APOE3 group, haplotype 2 (TC-/TC+) heterozygotes had an odds ratio of 0.66 (95% confidence interval, 0.42-0.99) for HOMA of insulin resistance after adjusting for 8 covariates. APOE promoter polymorphisms and their diplotypes are independently related with serum fasting insulin levels and HOMA index among Turks. 2011 Elsevier Inc. All rights reserved.", 
  "headline": "The APOE -219G/T and +113G/C polymorphisms affect insulin resistance among Turks", 
  "identifier": 18539, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "The APOE -219G/T and +113G/C polymorphisms affect insulin resistance among Turks", 
  "url": "https://aperta.ulakbim.gov.tr/record/18539"
}