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Effect of co-substrate sorbitol different feeding strategies on human growth hormone production by recombinant Pichia pastoris

Calik, Pinar; Bozkurt, Bahar; Zerze, Gul H.; Inankur, Bahar; Bayraktar, Eda; Boy, Erdem; Orman, Mehmet Ali; Acik, Eda; Ozdamar, Tuncer H.


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        "name": "Calik, Pinar"
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        "affiliation": "Middle E Tech Univ, Dept Biotechnol, Grad Sch Nat & Appl Sci, TR-06800 Ankara, Turkey", 
        "name": "Bozkurt, Bahar"
      }, 
      {
        "affiliation": "Middle E Tech Univ, Dept Chem Engn, Ind Biotechnol & Metab Engn Lab, TR-06800 Ankara, Turkey", 
        "name": "Zerze, Gul H."
      }, 
      {
        "affiliation": "Middle E Tech Univ, Dept Chem Engn, Ind Biotechnol & Metab Engn Lab, TR-06800 Ankara, Turkey", 
        "name": "Inankur, Bahar"
      }, 
      {
        "affiliation": "Middle E Tech Univ, Dept Chem Engn, Ind Biotechnol & Metab Engn Lab, TR-06800 Ankara, Turkey", 
        "name": "Bayraktar, Eda"
      }, 
      {
        "affiliation": "Middle E Tech Univ, Dept Chem Engn, Ind Biotechnol & Metab Engn Lab, TR-06800 Ankara, Turkey", 
        "name": "Boy, Erdem"
      }, 
      {
        "affiliation": "Middle E Tech Univ, Dept Chem Engn, Ind Biotechnol & Metab Engn Lab, TR-06800 Ankara, Turkey", 
        "name": "Orman, Mehmet Ali"
      }, 
      {
        "affiliation": "Middle E Tech Univ, Dept Chem Engn, Ind Biotechnol & Metab Engn Lab, TR-06800 Ankara, Turkey", 
        "name": "Acik, Eda"
      }, 
      {
        "affiliation": "Ankara Univ, Biochem React Engn Lab, Dept Chem Engn, TR-06100 Ankara, Turkey", 
        "name": "Ozdamar, Tuncer H."
      }
    ], 
    "description": "BACKGROUNDEffects of co-substrate sorbitol different feeding strategies on recombinant human growth hormone (rhGH) production by Pichia pastoris hGH-Mut(+) were investigated by eight designed experiments grouped as: (i) fed-batch methanol feeding without the co-substrate; (ii) fed-batch methanol feeding with pulse sorbitol feeding; (iii) fed-batch methanol feeding together with fed-batch sorbitol feeding at t=0-15h, followed by fed-batch methanol feeding; and (iv) fed-batch methanol and sorbitol feeding at t=0-30h, followed with fed-batch methanol feeding.", 
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      "issue": "9", 
      "pages": "1631-1640", 
      "title": "JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY", 
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    "title": "Effect of co-substrate sorbitol different feeding strategies on human growth hormone production by recombinant Pichia pastoris"
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