1 Ocak 2013 Dergi makalesi Açık Erişim

Calik, Pinar; Bozkurt, Bahar; Zerze, Gul H.; Inankur, Bahar; Bayraktar, Eda; Boy, Erdem; Orman, Mehmet Ali; Acik, Eda; Ozdamar, Tuncer H.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/17743</identifier>
  <creators>
    <creator>
      <creatorName>Calik, Pinar</creatorName>
      <givenName>Pinar</givenName>
      <familyName>Calik</familyName>
    </creator>
    <creator>
      <creatorName>Bozkurt, Bahar</creatorName>
      <givenName>Bahar</givenName>
      <familyName>Bozkurt</familyName>
      <affiliation>Middle E Tech Univ, Dept Biotechnol, Grad Sch Nat &amp; Appl Sci, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Zerze, Gul H.</creatorName>
      <givenName>Gul H.</givenName>
      <familyName>Zerze</familyName>
      <affiliation>Middle E Tech Univ, Dept Chem Engn, Ind Biotechnol &amp; Metab Engn Lab, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Inankur, Bahar</creatorName>
      <givenName>Bahar</givenName>
      <familyName>Inankur</familyName>
      <affiliation>Middle E Tech Univ, Dept Chem Engn, Ind Biotechnol &amp; Metab Engn Lab, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bayraktar, Eda</creatorName>
      <givenName>Eda</givenName>
      <familyName>Bayraktar</familyName>
      <affiliation>Middle E Tech Univ, Dept Chem Engn, Ind Biotechnol &amp; Metab Engn Lab, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Boy, Erdem</creatorName>
      <givenName>Erdem</givenName>
      <familyName>Boy</familyName>
      <affiliation>Middle E Tech Univ, Dept Chem Engn, Ind Biotechnol &amp; Metab Engn Lab, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Orman, Mehmet Ali</creatorName>
      <givenName>Mehmet Ali</givenName>
      <familyName>Orman</familyName>
      <affiliation>Middle E Tech Univ, Dept Chem Engn, Ind Biotechnol &amp; Metab Engn Lab, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Acik, Eda</creatorName>
      <givenName>Eda</givenName>
      <familyName>Acik</familyName>
      <affiliation>Middle E Tech Univ, Dept Chem Engn, Ind Biotechnol &amp; Metab Engn Lab, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozdamar, Tuncer H.</creatorName>
      <givenName>Tuncer H.</givenName>
      <familyName>Ozdamar</familyName>
      <affiliation>Ankara Univ, Biochem React Engn Lab, Dept Chem Engn, TR-06100 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Effect Of Co-Substrate Sorbitol Different Feeding Strategies On Human Growth Hormone Production By Recombinant Pichia Pastoris</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2013</publicationYear>
  <dates>
    <date dateType="Issued">2013-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/17743</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1002/jctb.4011</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">BACKGROUNDEffects of co-substrate sorbitol different feeding strategies on recombinant human growth hormone (rhGH) production by Pichia pastoris hGH-Mut(+) were investigated by eight designed experiments grouped as: (i) fed-batch methanol feeding without the co-substrate; (ii) fed-batch methanol feeding with pulse sorbitol feeding; (iii) fed-batch methanol feeding together with fed-batch sorbitol feeding at t=0-15h, followed by fed-batch methanol feeding; and (iv) fed-batch methanol and sorbitol feeding at t=0-30h, followed with fed-batch methanol feeding.</description>
  </descriptions>
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