1 Ocak 2013 Dergi makalesi Açık Erişim

Enginar, H.; Unak, P.; Lambrecht, F. Yurt; Muftuler, F. Zumrut Biber; Seyitoglu, B.; Yurt, A.; Yolcular, S.; Medine, E. I.; Bulduk, I.

Dublin Core

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  <dc:creator>Enginar, H.</dc:creator>
  <dc:creator>Unak, P.</dc:creator>
  <dc:creator>Lambrecht, F. Yurt</dc:creator>
  <dc:creator>Muftuler, F. Zumrut Biber</dc:creator>
  <dc:creator>Seyitoglu, B.</dc:creator>
  <dc:creator>Yurt, A.</dc:creator>
  <dc:creator>Yolcular, S.</dc:creator>
  <dc:creator>Medine, E. I.</dc:creator>
  <dc:creator>Bulduk, I.</dc:creator>
  <dc:date>2013-01-01</dc:date>
  <dc:description>The goal of this study was to determine the radiopharmaceutical potential of radioiodinated thebaine. Thebaine was extracted from dry capsules of opium poppy (Papaver somniferum L.), purified using high-performance liquid chromatography, and characterized with nuclear magnetic resonance and infrared spectroscopy. The purified thebaine was labeled with I-131 using the iodogen method. Normal and receptor-blockage biodistribution studies were performed in male Albino Wistar rats. The results of the tissue distribution studies showed that the uptake of I-131-thebaine in the stomach, large intestine, spinal cord, and prostate was higher than in the other tissues. A greater uptake of radiolabeled thebaine in the rat brain was observed in the midbrain and hypothalamus. We concluded that (1) the labeling yield of I-131-thebaine was high, (2) a large amount of I-131-thebaine remained in the midbrain and hypothalamus, and (3) I-131-thebaine had enough stability for diagnostic scanning.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/16501</dc:identifier>
  <dc:identifier>oai:zenodo.org:16501</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>MEDICINAL CHEMISTRY RESEARCH 22(7) 3459-3465</dc:source>
  <dc:title>Extraction, radiolabeling, and biodistribution of thebaine in rats</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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