1 Ocak 2013 Dergi makalesi Açık Erişim

Enginar, H.; Unak, P.; Lambrecht, F. Yurt; Muftuler, F. Zumrut Biber; Seyitoglu, B.; Yurt, A.; Yolcular, S.; Medine, E. I.; Bulduk, I.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/16501</identifier>
  <creators>
    <creator>
      <creatorName>Enginar, H.</creatorName>
      <givenName>H.</givenName>
      <familyName>Enginar</familyName>
      <affiliation>Afyon Kocatepe Univ, Dept Chem, Afyon, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Unak, P.</creatorName>
      <givenName>P.</givenName>
      <familyName>Unak</familyName>
      <affiliation>Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Lambrecht, F. Yurt</creatorName>
      <givenName>F. Yurt</givenName>
      <familyName>Lambrecht</familyName>
      <affiliation>Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Muftuler, F. Zumrut Biber</creatorName>
      <givenName>F. Zumrut Biber</givenName>
      <familyName>Muftuler</familyName>
      <affiliation>Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Seyitoglu, B.</creatorName>
      <givenName>B.</givenName>
      <familyName>Seyitoglu</familyName>
      <affiliation>Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yurt, A.</creatorName>
      <givenName>A.</givenName>
      <familyName>Yurt</familyName>
      <affiliation>Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yolcular, S.</creatorName>
      <givenName>S.</givenName>
      <familyName>Yolcular</familyName>
      <affiliation>Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Medine, E. I.</creatorName>
      <givenName>E. I.</givenName>
      <familyName>Medine</familyName>
      <affiliation>Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bulduk, I.</creatorName>
      <givenName>I.</givenName>
      <familyName>Bulduk</familyName>
      <affiliation>Bolvadin Alkaloid Factory, Bolvadin, Afyonkarahisar, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Extraction, Radiolabeling, And Biodistribution Of Thebaine In Rats</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2013</publicationYear>
  <dates>
    <date dateType="Issued">2013-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/16501</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s00044-012-0360-z</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The goal of this study was to determine the radiopharmaceutical potential of radioiodinated thebaine. Thebaine was extracted from dry capsules of opium poppy (Papaver somniferum L.), purified using high-performance liquid chromatography, and characterized with nuclear magnetic resonance and infrared spectroscopy. The purified thebaine was labeled with I-131 using the iodogen method. Normal and receptor-blockage biodistribution studies were performed in male Albino Wistar rats. The results of the tissue distribution studies showed that the uptake of I-131-thebaine in the stomach, large intestine, spinal cord, and prostate was higher than in the other tissues. A greater uptake of radiolabeled thebaine in the rat brain was observed in the midbrain and hypothalamus. We concluded that (1) the labeling yield of I-131-thebaine was high, (2) a large amount of I-131-thebaine remained in the midbrain and hypothalamus, and (3) I-131-thebaine had enough stability for diagnostic scanning.</description>
  </descriptions>
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