1 Ocak 2013 Dergi makalesi Açık Erişim

Enginar, H.; Unak, P.; Lambrecht, F. Yurt; Muftuler, F. Zumrut Biber; Seyitoglu, B.; Yurt, A.; Yolcular, S.; Medine, E. I.; Bulduk, I.

Citation Style Language JSON

{
  "DOI": "10.1007/s00044-012-0360-z", 
  "abstract": "The goal of this study was to determine the radiopharmaceutical potential of radioiodinated thebaine. Thebaine was extracted from dry capsules of opium poppy (Papaver somniferum L.), purified using high-performance liquid chromatography, and characterized with nuclear magnetic resonance and infrared spectroscopy. The purified thebaine was labeled with I-131 using the iodogen method. Normal and receptor-blockage biodistribution studies were performed in male Albino Wistar rats. The results of the tissue distribution studies showed that the uptake of I-131-thebaine in the stomach, large intestine, spinal cord, and prostate was higher than in the other tissues. A greater uptake of radiolabeled thebaine in the rat brain was observed in the midbrain and hypothalamus. We concluded that (1) the labeling yield of I-131-thebaine was high, (2) a large amount of I-131-thebaine remained in the midbrain and hypothalamus, and (3) I-131-thebaine had enough stability for diagnostic scanning.", 
  "author": [
    {
      "family": "Enginar", 
      "given": " H."
    }, 
    {
      "family": "Unak", 
      "given": " P."
    }, 
    {
      "family": "Lambrecht", 
      "given": " F. Yurt"
    }, 
    {
      "family": "Muftuler", 
      "given": " F. Zumrut Biber"
    }, 
    {
      "family": "Seyitoglu", 
      "given": " B."
    }, 
    {
      "family": "Yurt", 
      "given": " A."
    }, 
    {
      "family": "Yolcular", 
      "given": " S."
    }, 
    {
      "family": "Medine", 
      "given": " E. I."
    }, 
    {
      "family": "Bulduk", 
      "given": " I."
    }
  ], 
  "container_title": "MEDICINAL CHEMISTRY RESEARCH", 
  "id": "16501", 
  "issue": "7", 
  "issued": {
    "date-parts": [
      [
        2013, 
        1, 
        1
      ]
    ]
  }, 
  "page": "3459-3465", 
  "title": "Extraction, radiolabeling, and biodistribution of thebaine in rats", 
  "type": "article-journal", 
  "volume": "22"
}