1 Ocak 2013 Dergi makalesi Açık Erişim

Enginar, H.; Unak, P.; Lambrecht, F. Yurt; Muftuler, F. Zumrut Biber; Seyitoglu, B.; Yurt, A.; Yolcular, S.; Medine, E. I.; Bulduk, I.

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        "affiliation": "Afyon Kocatepe Univ, Dept Chem, Afyon, Turkey", 
        "name": "Enginar, H."
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      {
        "affiliation": "Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, Izmir, Turkey", 
        "name": "Unak, P."
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        "affiliation": "Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, Izmir, Turkey", 
        "name": "Lambrecht, F. Yurt"
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      {
        "affiliation": "Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, Izmir, Turkey", 
        "name": "Muftuler, F. Zumrut Biber"
      }, 
      {
        "affiliation": "Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, Izmir, Turkey", 
        "name": "Seyitoglu, B."
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      {
        "affiliation": "Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, Izmir, Turkey", 
        "name": "Yurt, A."
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      {
        "affiliation": "Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, Izmir, Turkey", 
        "name": "Yolcular, S."
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        "affiliation": "Ege Univ, Inst Nucl Sci, Dept Nucl Applicat, Izmir, Turkey", 
        "name": "Medine, E. I."
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        "affiliation": "Bolvadin Alkaloid Factory, Bolvadin, Afyonkarahisar, Turkey", 
        "name": "Bulduk, I."
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    "description": "The goal of this study was to determine the radiopharmaceutical potential of radioiodinated thebaine. Thebaine was extracted from dry capsules of opium poppy (Papaver somniferum L.), purified using high-performance liquid chromatography, and characterized with nuclear magnetic resonance and infrared spectroscopy. The purified thebaine was labeled with I-131 using the iodogen method. Normal and receptor-blockage biodistribution studies were performed in male Albino Wistar rats. The results of the tissue distribution studies showed that the uptake of I-131-thebaine in the stomach, large intestine, spinal cord, and prostate was higher than in the other tissues. A greater uptake of radiolabeled thebaine in the rat brain was observed in the midbrain and hypothalamus. We concluded that (1) the labeling yield of I-131-thebaine was high, (2) a large amount of I-131-thebaine remained in the midbrain and hypothalamus, and (3) I-131-thebaine had enough stability for diagnostic scanning.", 
    "doi": "10.1007/s00044-012-0360-z", 
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    "journal": {
      "issue": "7", 
      "pages": "3459-3465", 
      "title": "MEDICINAL CHEMISTRY RESEARCH", 
      "volume": "22"
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    "title": "Extraction, radiolabeling, and biodistribution of thebaine in rats"
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