1 Ocak 2019 Dergi makalesi Açık Erişim

Sezer, Umran Aydemir; Sahin, Isa; Aru, Basak; Olmez, Hulya; Demirel, Gulderen Yanikkaya; Sezer, Serdar

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/99881</identifier>
  <creators>
    <creator>
      <creatorName>Sezer, Umran Aydemir</creatorName>
      <givenName>Umran Aydemir</givenName>
      <familyName>Sezer</familyName>
    </creator>
    <creator>
      <creatorName>Sahin, Isa</creatorName>
      <givenName>Isa</givenName>
      <familyName>Sahin</familyName>
      <affiliation>TUBITAK Marmara Res Ctr, Inst Chem Technol, TR-41470 Kocaeli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Aru, Basak</creatorName>
      <givenName>Basak</givenName>
      <familyName>Aru</familyName>
      <affiliation>Yeditepe Univ, Sch Med, Dept Immunol Sect, TR-34755 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Olmez, Hulya</creatorName>
      <givenName>Hulya</givenName>
      <familyName>Olmez</familyName>
      <affiliation>TUBITAK Marmara Res Ctr, Mat Inst, TR-41470 Kocaeli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Demirel, Gulderen Yanikkaya</creatorName>
      <givenName>Gulderen Yanikkaya</givenName>
      <familyName>Demirel</familyName>
      <affiliation>Yeditepe Univ, Sch Med, Dept Immunol Sect, TR-34755 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sezer, Serdar</creatorName>
      <givenName>Serdar</givenName>
      <familyName>Sezer</familyName>
    </creator>
  </creators>
  <titles>
    <title>Cytotoxicity, Bactericidal And Hemostatic Evaluation Of Oxidized Cellulose Microparticles: Structure And Oxidation Degree Approach</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/99881</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.carbpol.2019.05.005</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Oxidized cellulose is the most used hemostatic materials in clinical applications. In addition to its perfect hemostatic efficiency, it is degradable under in vivo conditions and supremely prevents bacterial growth. On the other hand, one of the drawbacks of the oxidized cellulose is cytotoxicity due to the strongly acidic nature during degradation. There is a number of commercially available oxidized cellulose products which are derived from regenerated and non-regenerated cellulose. On the other hand, the effect of oxidation degree and structure (regenerated or non-regenerated) on product efficiency is undetermined. Moreover, oxidation degree which is primary factor for both bactericidal and hemostatic efficiency is also crucial for assessment of the product. In this study, oxidized cellulose versus oxidized regenerated cellulose microparticles with various oxidation degree was produced and characterized. Comparative studies were conducted in terms of bactericidal and hemostatic efficiencies in addition to cytotoxicity. The results could be a reference for the optimized oxidized cellulose product for the hemostatic applications.</description>
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