1 Ocak 2020 Dergi makalesi Açık Erişim

Subasi, Elif; Atalay, Esra Bulut; Erdogan, Duygu; Sen, Betill; Pakyapan, Bilge; Kayali, Hulya Ayar

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/9615</identifier>
  <creators>
    <creator>
      <creatorName>Subasi, Elif</creatorName>
      <givenName>Elif</givenName>
      <familyName>Subasi</familyName>
      <affiliation>Dokuz Eylul Univ, Fac Sci, Dept Chem, TR-35160 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Atalay, Esra Bulut</creatorName>
      <givenName>Esra Bulut</givenName>
      <familyName>Atalay</familyName>
      <affiliation>Dokuz Eylul Univ, Izmir Int Biomed &amp; Genome Inst, TR-35340 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Erdogan, Duygu</creatorName>
      <givenName>Duygu</givenName>
      <familyName>Erdogan</familyName>
      <affiliation>Dokuz Eylul Univ, Izmir Int Biomed &amp; Genome Inst, TR-35340 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sen, Betill</creatorName>
      <givenName>Betill</givenName>
      <familyName>Sen</familyName>
      <affiliation>Dokuz Eylul Univ, Fac Sci, Dept Phys, TR-35160 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Pakyapan, Bilge</creatorName>
      <givenName>Bilge</givenName>
      <familyName>Pakyapan</familyName>
      <affiliation>Ege Univ, Inst Sci &amp; Technol, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kayali, Hulya Ayar</creatorName>
      <givenName>Hulya Ayar</givenName>
      <familyName>Kayali</familyName>
    </creator>
  </creators>
  <titles>
    <title>Synthesis And Characterization Of Thiosemicarbazone-Functionalized Organoruthenium (Ii)-Arene Complexes: Investigation Of Antitumor Characteristics In Colorectal Cancer Cell Lines</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/9615</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.msec.2019.110152</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">In the current study, organoruthenium(II)-arene complexes (I-IV) have been prepared by the reaction of ({(eta(6)-pcym)RuCl}(2)(mu-Cl)(2)] with new thiosemicarbazones (TSC1-4).The isolate was analyzed using elemental analysis, FT-IR, H-1 and C-13 NMR spectroscopy and single-crystal XRD. Subsequently, the complexes and TSC ligands were assessed for anticancer properties in vitro against three different colorectal cancer stage's cell lines (Caco-2, DLD-1, and SW620) and a noncancerous cell line (CCD18Co). The complexes (I-IV) showed higher cytotoxicity with low IC50 values as 0.1-0.33 mu M in colorectal cell lines except for SW620 (47.4-84.20 mu M) than in a noncancerous cell. Complex I was 2.8 and 24.5-fold more active against Caco-2 and DLD-1 than CCD18Co, respectively. The complexes (I-IV) accumulated at a high concentration in the cell nuclei and caused cell cycle arrest by affecting the G0/G1 and/or G2/M phase and showed high binding affinity with CT-DNA (Kb = 10(4) M-1). The expression of Caspase-3 and Caspase-9 apoptosis-related protein levels was slightly upregulated and Atg5 autophagy-related protein level was clearly downregulated according to control and 5-FU-treated cells after complex I and II treatment. Furthermore, it was observed that cytotoxicity of the complexes is decreased while cancer progresses. Altogether, this study indicates that all organoruthenium (II)-arene complexes (particularly complex I) can be a promising alternative to platinum counterparts in cancer treatment.</description>
  </descriptions>
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