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Rapid and reliable 25-OH vitamin D2 and 25-OH vitamin D3 measurements by multitasker LC-MS/MS

Goren, Ahmet C.; Sahin, Gozde; Gumilcineli, Ismail; Binici, Burcu


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{
  "DOI": "10.25135/jcm.13.18.02.070", 
  "abstract": "The 25-OH Vitamin D2 and 25-OH Vitamin D3 measurement method was validated using a Zivak Multitasker Fully Automated Sample Preparation and Injection System coupled to a MS detector. The current method incorporates all sample preparations, SPE clean up procedures, LC and MS facilities into an all in one system. This system can report patient data within 6 minutes including the SPE and Sample preparation and mass spectrometry analysis time. The correlation coefficient of the developed method was greater than 0.99 for measurands, 25-OH-vitamin Ds, in the calibration range. The measurement uncertainty of the measurements were evaluated and found as 7.7 % and 7.6 % for 25-OH vitamin D2 and 25-OH-vitamin D3, respectively.", 
  "author": [
    {
      "family": "Goren", 
      "given": " Ahmet C."
    }, 
    {
      "family": "Sahin", 
      "given": " Gozde"
    }, 
    {
      "family": "Gumilcineli", 
      "given": " Ismail"
    }, 
    {
      "family": "Binici", 
      "given": " Burcu"
    }
  ], 
  "container_title": "JOURNAL OF CHEMICAL METROLOGY", 
  "id": "93197", 
  "issue": "1", 
  "issued": {
    "date-parts": [
      [
        2018, 
        1, 
        1
      ]
    ]
  }, 
  "page": "17-25", 
  "title": "Rapid and reliable 25-OH vitamin D2 and 25-OH vitamin D3 measurements by multitasker LC-MS/MS", 
  "type": "article-journal", 
  "volume": "12"
}
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