1 Ocak 2017 Dergi makalesi Açık Erişim

Okten, Salih; Cakmak, Osman; Tekin, Saban; Koprulu, Tugba Kul

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        "affiliation": "Kirikkale Univ, Fac Educ, Div Sci Educ, Dept Maths & Sci Educ, TR-71450 Yahsihan, Kirikkale, Turkey", 
        "name": "Okten, Salih"
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      {
        "affiliation": "Istanbul Gelisim Univ, Sch Hlth Sci, Dept Nutr & Dietet, Istanbul, Turkey", 
        "name": "Cakmak, Osman"
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      {
        "affiliation": "Tubitak MAM, Inst Genet Engn & Biotechnol, TR-41470 Gebze, Kocaeli, Turkey", 
        "name": "Tekin, Saban"
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      {
        "affiliation": "Gaziosmanpasa Univ, Fac Art & Sci, Dept Biol, TR-60240 Tokat, Turkey", 
        "name": "Koprulu, Tugba Kul"
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    "description": "Background: Brominated 8-hydroxy, 8-methoxy, 8-amino quinolines 5, 6, 8, 9 and novel cyano 8-hydroxyquinolines 11, 12 were evaluated in vitro for their anticancer effects on various cell lines. 5,7-Dibromo-5, 7-bromo-6, 7-cyano-11 and 5,7-dicyano-12 8-hydroxyquinolines were shown to have strong antiproliferative activity against various tumor cell lines, including C6 (rat brain tumor), HeLa (human cervix carcinoma), and HT29 (human colon carcinoma) with IC50 values ranged from 6.7 to 25.6 mu g/mL.", 
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      "issue": "12", 
      "pages": "1415-1424", 
      "title": "LETTERS IN DRUG DESIGN & DISCOVERY", 
      "volume": "14"
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    "publication_date": "2017-01-01", 
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    "title": "A SAR Study: Evaluation of Bromo Derivatives of 8-Substituted Quinolines as Novel Anticancer Agents"
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