1 Ocak 2017 Dergi makalesi Açık Erişim

Okten, Salih; Cakmak, Osman; Tekin, Saban; Koprulu, Tugba Kul

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/90141</identifier>
  <creators>
    <creator>
      <creatorName>Okten, Salih</creatorName>
      <givenName>Salih</givenName>
      <familyName>Okten</familyName>
      <affiliation>Kirikkale Univ, Fac Educ, Div Sci Educ, Dept Maths &amp; Sci Educ, TR-71450 Yahsihan, Kirikkale, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Cakmak, Osman</creatorName>
      <givenName>Osman</givenName>
      <familyName>Cakmak</familyName>
      <affiliation>Istanbul Gelisim Univ, Sch Hlth Sci, Dept Nutr &amp; Dietet, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tekin, Saban</creatorName>
      <givenName>Saban</givenName>
      <familyName>Tekin</familyName>
      <affiliation>Tubitak MAM, Inst Genet Engn &amp; Biotechnol, TR-41470 Gebze, Kocaeli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Koprulu, Tugba Kul</creatorName>
      <givenName>Tugba Kul</givenName>
      <familyName>Koprulu</familyName>
      <affiliation>Gaziosmanpasa Univ, Fac Art &amp; Sci, Dept Biol, TR-60240 Tokat, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>A Sar Study: Evaluation Of Bromo Derivatives Of 8-Substituted Quinolines As Novel Anticancer Agents</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/90141</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.2174/1570180814666170504150050</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Background: Brominated 8-hydroxy, 8-methoxy, 8-amino quinolines 5, 6, 8, 9 and novel cyano 8-hydroxyquinolines 11, 12 were evaluated in vitro for their anticancer effects on various cell lines. 5,7-Dibromo-5, 7-bromo-6, 7-cyano-11 and 5,7-dicyano-12 8-hydroxyquinolines were shown to have strong antiproliferative activity against various tumor cell lines, including C6 (rat brain tumor), HeLa (human cervix carcinoma), and HT29 (human colon carcinoma) with IC50 values ranged from 6.7 to 25.6 mu g/mL.</description>
  </descriptions>
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