Yayınlanmış 1 Ocak 2017
| Sürüm v1
Dergi makalesi
Açık
A SAR Study: Evaluation of Bromo Derivatives of 8-Substituted Quinolines as Novel Anticancer Agents
Oluşturanlar
- 1. Kirikkale Univ, Fac Educ, Div Sci Educ, Dept Maths & Sci Educ, TR-71450 Yahsihan, Kirikkale, Turkey
- 2. Istanbul Gelisim Univ, Sch Hlth Sci, Dept Nutr & Dietet, Istanbul, Turkey
- 3. Tubitak MAM, Inst Genet Engn & Biotechnol, TR-41470 Gebze, Kocaeli, Turkey
- 4. Gaziosmanpasa Univ, Fac Art & Sci, Dept Biol, TR-60240 Tokat, Turkey
Açıklama
Background: Brominated 8-hydroxy, 8-methoxy, 8-amino quinolines 5, 6, 8, 9 and novel cyano 8-hydroxyquinolines 11, 12 were evaluated in vitro for their anticancer effects on various cell lines. 5,7-Dibromo-5, 7-bromo-6, 7-cyano-11 and 5,7-dicyano-12 8-hydroxyquinolines were shown to have strong antiproliferative activity against various tumor cell lines, including C6 (rat brain tumor), HeLa (human cervix carcinoma), and HT29 (human colon carcinoma) with IC50 values ranged from 6.7 to 25.6 mu g/mL.
Dosyalar
bib-f11b0f8e-1509-4b8c-b910-ffea9de7d2f4.txt
Dosyalar
(210 Bytes)
| Ad | Boyut | Hepisini indir |
|---|---|---|
|
md5:6769b180e26a2c624b7d358e5faad8cf
|
210 Bytes | Ön İzleme İndir |